Metabolite profiling as an aid to metabolic engineering in plants

被引:105
作者
Trethewey, RN [1 ]
机构
[1] Metanom GmbH & Co KGaA, D-10589 Berlin, Germany
关键词
D O I
10.1016/j.pbi.2003.12.003
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The past decade has seen some impressive successes in the metabolic engineering of biotechnologically important plant pathways. However, plant metabolic engineering currently proceeds more by trial and error than by intelligent system design. A change in philosophy away from studying pathways in isolation and towards studying metabolism as a network is necessary. To support this development, improvements in technologies. for metabolic analysis, a wider adoption of metabolite-profiling approaches and significant innovations in data analysis methodologies are required.
引用
收藏
页码:196 / 201
页数:6
相关论文
共 62 条
  • [1] Trends in lignin modification: a comprehensive analysis of the effects of genetic manipulations/mutations on lignification and vascular integrity
    Anterola, AM
    Lewis, NG
    [J]. PHYTOCHEMISTRY, 2002, 61 (03) : 221 - 294
  • [2] Ap Rees T., 1994, Plant Cell and Environment, V17, P587, DOI 10.1111/j.1365-3040.1994.tb00151.x
  • [3] Golden rice:: Introducing the β-carotene biosynthesis pathway into rice endosperm by genetic engineering to defeat vitamin A deficiency
    Beyer, P
    Al-Babili, S
    Ye, XD
    Lucca, P
    Schaub, P
    Welsch, R
    Potrykus, I
    [J]. JOURNAL OF NUTRITION, 2002, 132 (03) : 506S - 510S
  • [4] Constitutive expression of the β-ketothiolase gene in transgenic plants.: A major obstacle for obtaining polyhydroxybutyrate-producing plants
    Bohmert, K
    Balbo, I
    Steinbüchel, A
    Tischendorf, G
    Willmitzer, L
    [J]. PLANT PHYSIOLOGY, 2002, 128 (04) : 1282 - 1290
  • [5] Transgenic Arabidopsis plants can accumulate polyhydroxybutyrate to up to 4% of their fresh weight
    Bohmert, K
    Balbo, I
    Kopka, J
    Mittendorf, V
    Nawrath, C
    Poirier, Y
    Tischendorf, G
    Trethewey, RN
    Willmitzer, L
    [J]. PLANTA, 2000, 211 (06) : 841 - 845
  • [6] Plant genetics - Something to sniff at: Unbottling floral scent
    Brown, K
    [J]. SCIENCE, 2002, 296 (5577) : 2327 - 2329
  • [7] Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content
    Cahoon, EB
    Hall, SE
    Ripp, KG
    Ganzke, TS
    Hitz, WD
    Coughlan, SJ
    [J]. NATURE BIOTECHNOLOGY, 2003, 21 (09) : 1082 - 1087
  • [8] Engineering central metabolism in crop species: learning the system
    Carrari, F
    Urbanczyk-Wochniak, E
    Willmitzer, L
    Fernie, AR
    [J]. METABOLIC ENGINEERING, 2003, 5 (03) : 191 - 200
  • [9] Plant metabolic engineering
    DellaPenna, D
    [J]. PLANT PHYSIOLOGY, 2001, 125 (01) : 160 - 163
  • [10] The phenylpropanoid pathway and plant defence - a genomics perspective
    Dixon, RA
    Achnine, L
    Kota, P
    Liu, CJ
    Reddy, MSS
    Wang, LJ
    [J]. MOLECULAR PLANT PATHOLOGY, 2002, 3 (05) : 371 - 390