The role of miRNAs in the pathogenesis and diagnosis of B-cell lymphomas

被引：61

作者：

Di Lisio, Lorena ^{[1
]}

Martinez, Nerea ^{[1
]}

Montes-Moreno, Santiago ^{[1
]}

Piris-Villaespesa, Miguel ^{[2
]}

Sanchez-Beato, Margarita ^{[3
]}

Piris, Miguel A. ^{[1
]}

机构：

[1] HUMV, Inst Formac & Invest Marques de Valdecilla IFIMAV, Santander, Spain

[2] Hosp Puerta de Hierro, Dept Hematol, Madrid, Spain

[3] Fdn Hosp U Puerta de Hierro Majadahonda, Med Oncol Serv, Oncohemathol Unit, Madrid, Spain

来源：

BLOOD | 2012年 / 120卷 / 09期

关键词：

CHRONIC LYMPHOCYTIC-LEUKEMIA; SARCOMA-ASSOCIATED HERPESVIRUS; INDUCED CYTIDINE DEAMINASE; MICRORNA EXPRESSION PROFILE; PROTEIN-SYNTHESIS; DOWN-REGULATION; CLL PATIENTS; MYC; RNA; ACTIVATION;

D O I：

10.1182/blood-2012-05-402784

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is a demand to understand B-cell lymphoma pathogenesis better, to identify new markers, and to define multiple lymphoproliferative disorders more accurately. MicroRNAs (miRNAs) are regulators of protein translation, comprising a group of more than 1500 short noncoding single-strand RNA molecules of approximately 22 nucleotides in length. They are easily detectable in fresh or paraffin-embedded diagnostic tissue and serum. Expression of individual miRNAs and miRNA signatures allows specific cell-differentiation stages to be identified, and is a powerful diagnostic and prognostic method. Here we review what is known about the pathogenic relevance of miRNAs, and use of miRNAs for the diagnosis and prognosis of B-cell lymphomas. Most of the published data concern chronic lymphocytic lymphoma and diffuse large B-cell lymphoma, and implicate miRNAs in the pathogenesis of these diseases. They identify miRNAs that could be used for diagnosis, prognosis, or prediction of response to specific therapies. (Blood. 2012;120(9):1782-1790)

引用

页码：1782 / 1790

页数：9

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