Centromeres from telomeres?: The centromeric region of the Y chromosome of Drosophila melanogaster contains a tandem array of telomeric HeT-A- and TART-related sequences

被引：51

作者：

Agudo, M

Losada, A

Abad, JP

Pimpinelli, S

Ripoll, P

Villasante, A ^{[1
]}

机构：

[1] Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

[2] Univ Rome La Sapienza, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy

来源：

NUCLEIC ACIDS RESEARCH | 1999年 / 27卷 / 16期

关键词：

D O I：

10.1093/nar/27.16.3318

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytological and cytogenetic studies have previously defined the region needed for centromeric function in the Y chromosome of Drosophila melanogaster, We have identified a YAC clone that originated from this region. Molecular analysis of the YAC and genomic DNAs has allowed the description of a satellite DNA made of telomeric HeT-A- and TART-derived sequences and the construction of a long-range physical map of the heterochromatic region h18. Sequences within the YAC clone are conserved in the centromeric region of the sibling species Drosophila simulans. That telomere-derived DNA now forms part of the centromeric region of the Y chromosome could indicate a telomeric origin of this centromere, The existence of common determinants for the function of both centromeres and telomeres is discussed.

引用

页码：3318 / 3324

页数：7

共 46 条

[1] DODECA SATELLITE - A CONSERVED G+C-RICH SATELLITE FROM THE CENTROMERIC HETEROCHROMATIN OF DROSOPHILA-MELANOGASTER [J].