BASH: a tool for managing BeadArray spatial artefacts

被引：54

作者：

Cairns, J. M. ^{[1
]}

Dunning, M. J. ^{[1
]}

Ritchie, M. E. ^{[1
]}

Russell, R. ^{[1
]}

Lynch, A. G. ^{[1
]}

机构：

[1] Canc Res UK, Cambridge Res Inst, Li Ka Shing Ctr, Cambridge CB2 0RE, England

来源：

BIOINFORMATICS | 2008年 / 24卷 / 24期

关键词：

D O I：

10.1093/bioinformatics/btn557

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

With their many replicates and their random layouts, Illumina BeadArrays provide greater scope for detecting spatial artefacts than do other microarray technologies. They are also robust to artefact exclusion, yet there is a lack of tools that can perform these tasks for Illumina. We present BASH, a tool for this purpose. BASH adopts the concepts of Harshlight, but implements them in a manner that utilizes the unique characteristics of the Illumina technology. Using bead-level data, spatial artefacts of various kinds can thus be identified and excluded from further analyses.

引用

页码：2921 / 2922

页数：2

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