Non-coding RNAs and EZH2 interactions in cancer: Long and short tales from the transcriptome

被引：69

作者：

Benetatos, Leonidas ^{[1
]}

Voulgaris, Evangelos ^{[2
]}

Vartholomatos, George ^{[3
]}

Hatzimichael, Eleftheria ^{[4
,5
]}

机构：

[1] Gen Hosp Preveza, Blood Bank, Preveza 48100, Greece

[2] 217 Mil Hosp Ioannina, Ioannina, Greece

[3] Univ Hosp Ioannina, Mol Biol Lab, Ioannina, Greece

[4] Univ Hosp Ioannina, Dept Hematol, Ioannina, Greece

[5] Univ Ioannina, Canc Biobank Ctr, GR-45110 Ioannina, Greece

来源：

INTERNATIONAL JOURNAL OF CANCER | 2013年 / 133卷 / 02期

关键词：

microRNAs; lncRNAs; EZH2; cancer; chromatin modifications; ZESTE HOMOLOG 2; HISTONE METHYLTRANSFERASE EZH2; TUMOR-SUPPRESSIVE FUNCTIONS; EPIGENETIC MODIFICATIONS; CELL-PROLIFERATION; NASOPHARYNGEAL CARCINOMA; DNA METHYLOMES; GENE EZH2; MICRORNA-101; EXPRESSION;

D O I：

10.1002/ijc.27859

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A large amount of data indicates that non-coding RNAs represent more than the dark matter of the genome. Both microRNAs and long non-coding RNAs are involved in several fundamental biologic processes, and their deregulation may lead in oncogenesis. Interacting with the Polycomb-repressive complex 2 subunit EZH2, they could affect the expression of protein-coding genes and form feedback networks and autoregulatory loops. They can also form networks with upstream and downstream important factors, in which EZH2 represent the stabilizing factor of the pathway. As such non-coding RNAs affect the epigenetic modifications leading to malignant transformation.

引用

页码：267 / 274

页数：8

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