Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry

被引：418

作者：

Berdasco, Maria ^{[1
]}

Esteller, Manel ^{[1
,2
]}

机构：

[1] L Hosp Llobregat, Canc Epigenet Grp, Canc Epigenet & Biol Program PEBC, Bellvitge Inst Biomed Res IDIBELL, Barcelona 08907, Catalonia, Spain

[2] ICREA, Barcelona 08010, Catalonia, Spain

来源：

DEVELOPMENTAL CELL | 2010年 / 19卷 / 05期

关键词：

CPG-ISLAND METHYLATION; ACUTE MYELOID-LEUKEMIA; TUMOR-SUPPRESSOR GENES; EMBRYONIC STEM-CELLS; SMALL-MOLECULE COMPOUNDS; DNA METHYLATION; COLORECTAL-CANCER; HISTONE-MODIFICATION; PROSTATE-CANCER; X-CHROMOSOME;

D O I：

10.1016/j.devcel.2010.10.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Appropriate patterns of DNA methylation and histone modifications are required to assure cell identity, and their deregulation can contribute to human diseases, such as cancer Our aim here is to provide an overview of how epigenetic factors, including genomic DNA methylation, histone modifications, and microRNA regulation, contribute to normal development, paying special attention to their role in regulating tissue-specific genes In addition, we summarize how these epigenetic patterns go awry during human cancer development The possibility of "resetting" the abnormal cancer epigenome by applying pharmacological or genetic strategies is also discussed

引用

页码：698 / 711

页数：14

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