Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites

被引:375
作者
Saenz, Steven A. [1 ]
Taylor, Betsy C. [1 ]
Artis, David [1 ]
机构
[1] Univ Penn, Dept Pathobiol, Sch Vet Med, Philadelphia, PA 19104 USA
关键词
TSLP; IL-25; IL-33; mucosal immunity; Th2 cytokine responses;
D O I
10.1111/j.1600-065X.2008.00713.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
There is compelling evidence that epithelial cells (ECs) at mucosal surfaces, beyond their role in creating a physical barrier, are integral components of innate and adaptive immunity. The capacity of these cells to license the functions of specific immune cell populations in the airway and gastrointestinal tract offers the prospect of novel therapeutic strategies to target multiple inflammatory diseases in which barrier immunity is dysregulated. In this review, we discuss the critical functions of EC-derived thymic stromal lymphopoietin (TSLP), interleukin-25 (IL-25), and IL-33 in the development and regulation of T-helper 2 (Th2) cytokine-dependent immune responses. We first highlight recent data that have provided new insights into the factors that control expression of this triad of cytokines and their receptors. In addition, we review their proinflammatory and immunoregulatory functions in models of mucosal infection and inflammation. Lastly, we discuss new findings indicating that despite their diverse structural features and differential expression of their receptors, TSLP, IL-25, and IL-33 cross-regulate one another and share overlapping properties that influence Th2 cytokine-dependent responses at mucosal sites.
引用
收藏
页码:172 / 190
页数:19
相关论文
共 138 条
[71]   Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis [J].
Li, Mei ;
Hener, Pierre ;
Zhang, Zhikun ;
Kato, Shigeaki ;
Metzger, Daniel ;
Chambon, Pierre .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (31) :11736-11741
[72]   An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment [J].
Liang, Spencer C. ;
Long, Andrew J. ;
Bennett, Frann ;
Whitters, Matthew J. ;
Karim, Riyez ;
Collins, Mary ;
Goldman, Samuel J. ;
Dunussi-Joannopoulos, Kyriaki ;
Williams, Cara M. M. ;
Wright, Jill F. ;
Fouser, Lynette A. .
JOURNAL OF IMMUNOLOGY, 2007, 179 (11) :7791-7799
[73]   Neutrophilic airway inflammation and IL-17 [J].
Lindén, A ;
Adachi, M .
ALLERGY, 2002, 57 (09) :769-775
[74]   Thymic stromal lymphopoietin: master switch for allergic inflammation [J].
Liu, YJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (02) :269-273
[75]   Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation [J].
Liu, Yong-Jun .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (02) :238-244
[76]   TSLP: An epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation [J].
Liu, Yong-Jun ;
Soumelis, Vasilli ;
Watanabe, Norihiko ;
Ito, Tomoki ;
Wang, Yul-Hsi ;
de Waal Malefyt, Rene ;
Omori, Miyuki ;
Zhou, Baohua ;
Ziegler, Steven F. .
ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 :193-219
[77]   T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function [J].
Löhning, M ;
Stroehmann, A ;
Coyle, AJ ;
Grogan, JL ;
Lin, S ;
Gutierrez-Ramos, JC ;
Levinson, D ;
Radbruch, A ;
Kamradt, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :6930-6935
[78]   Involvement of TNF receptor-associated factor 6 in IL-25 receptor signaling [J].
Maezawa, Y ;
Nakajima, H ;
Suzuki, K ;
Tamachi, T ;
Ikeda, K ;
Inoue, J ;
Saito, Y ;
Iwamoto, I .
JOURNAL OF IMMUNOLOGY, 2006, 176 (02) :1013-1018
[79]   Development of regulatory T cells requires IL-7Rα stimulation by IL-7 or TSLP [J].
Mazzucchelli, Renata ;
Hixon, Julie A. ;
Spolski, Rosanne ;
Chen, Xin ;
Li, Wen Qing ;
Hall, Veronica L. ;
Willette-Brown, Jami ;
Hurwitz, Arthur A. ;
Leonard, Warren J. ;
Durum, Scott K. .
BLOOD, 2008, 112 (08) :3283-3292
[80]   IL-33 reduces the development of atherosclerosis [J].
Miller, Ashley M. ;
Xu, Damo ;
Asquith, Darren L. ;
Denby, Laura ;
Li, Yubin ;
Sattar, Naveed ;
Baker, Andrew H. ;
McInnes, Iain B. ;
Liew, Foo Y. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (02) :339-346