Positron emission tomography in patients with breast cancer using 18F-3′-deoxy-3′-fluoro-L-thymidine (18F-FLT) -: a pilot study

被引：53

作者：

Been, LB

Elsinga, PH

de Vries, J

Cobben, DCP

Jager, PL

Hoekstra, HJ

Suurmeijer, AJH

机构：

[1] Univ Groningen, Med Ctr, Dept Surg Oncol, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen, PET Ctr, Med Ctr, NL-9700 RB Groningen, Netherlands

[3] Univ Groningen, Med Ctr, Dept Pathol & Lab Med, NL-9700 RB Groningen, Netherlands

来源：

EJSO | 2006年 / 32卷 / 01期

关键词：

F-13-FLT; breast cancer; oncology; positron emission tomography; PET;

D O I：

10.1016/j.ejso.2005.09.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: This pilot study investigated the feasibility of F-18-3'-deoxy-3'-fluoro-L-thymidine (F-18-FLT) as a positron emission tomography (PET) tracer for the visualisation of breast cancer. Methods: Patients with breast cancer underwent F-18-FLT-PET prior to surgery. The uptake of F-18-FLT was determined in the primary tumour and in the axilla. Results: Eight tumours were visualized by F-18-FLT-PET with a mean uptake value (SUVmean) of 1.7 and mean tumour-non-tumour ratio (TNT) of 5.0. In seven patients, axillary lymph-node metastases were found at pathological examinations, however, F-18-FLT-PET showed uptake in only two large (and clinically evident) lymph-node metastases. Conclusions: F-18-FLT shows uptake in most primary breast tumours and in large axillary lymph-node metastases. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：39 / 43

页数：5

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