Pyridine Group Assisted Addition of Diazo-Compounds to Imines in the 3-CC Reaction of 2-Aminopyridines, Aldehydes, and Diazo-Compounds

被引：43

作者：

Gulevich, Anton V. ^{[1
]}

Helan, Victoria ^{[1
]}

Wink, Donald J. ^{[1
]}

Gevorgyan, Vladimir ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 04期

基金：

美国国家卫生研究院;

关键词：

ASYMMETRIC MANNICH REACTION; CHIRAL DICARBOXYLIC-ACID; CATALYZED REACTIONS; EFFICIENT; MIGRATION; ACYLDIAZOMETHANES; 1,2-ARYL; DESIGN;

D O I：

10.1021/ol400148r

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A novel three-component coupling (3-CC) reaction of 2-aminoazines, aromatic aldehydes, and diazo-compounds producing polyfunctional beta-amino-alpha-diazo-compounds has been developed. The reaction features an unprecedented heterocycle-assisted addition of a diazo-compound to an imine. The obtained diazoesters were efficiently converted into valuable heterocycles as well as beta-amino acid derivatives.

引用

收藏

页码：956 / 959

页数：4

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