Catalytic C-H functionalization by metal carbenoid and nitrenoid insertion

被引：1955

作者：

Davies, Huw M. L. ^{[1
]}

Manning, James R. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

NATURE | 2008年 / 451卷 / 7177期

关键词：

D O I：

10.1038/nature06485

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Novel reactions that can selectively functionalize carbon - hydrogen bonds are of intense interest to the chemical community because they offer new strategic approaches for synthesis. A very promising 'carbon - hydrogen functionalization' method involves the insertion of metal carbenes and nitrenes into C - H bonds. This area has experienced considerable growth in the past decade, particularly in the area of enantioselective intermolecular reactions. Here we discuss several facets of these kinds of C - H functionalization reactions and provide a perspective on how this methodology has affected the synthesis of complex natural products and potential pharmaceutical agents.

引用

页码：417 / 424

页数：8

共 91 条

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