Diversifying microRNA sequence and function

被引：955

作者：

Ameres, Stefan L. ^{[1
]}

Zamore, Phillip D. ^{[2
,3
]}

机构：

[1] Acad Sci IMBA, Inst Mol Biotechnol Austrian, A-1030 Vienna, Austria

[2] Howard Hughes Med Inst, Worcester, MA 01605 USA

[3] Univ Massachusetts, Sch Med, Worcester, MA 01605 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2013年 / 14卷 / 08期

关键词：

GENOME-WIDE ANALYSIS; DOUBLE-STRANDED-RNA; MESSENGER-RNA; NUCLEAR EXPORT; IN-VIVO; GENE-EXPRESSION; PRE-MICRORNA; TRANSLATIONAL REPRESSION; MAMMALIAN MICRORNAS; C-ELEGANS;

D O I：

10.1038/nrm3611

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only now beginning to understand how they are generated, assembled into functional complexes and destroyed. Various mechanisms have now been identified that regulate miRNA stability and that diversify miRNA sequences to create distinct isoforms. The production of different isoforms of individual miRNAs in specific cells and tissues may have broader implications for miRNA-mediated gene expression control. Rigorously testing the many discrepant models for how miRNAs function using quantitative biochemical measurements made in vivo and in vitro remains a major challenge for the future.

引用

页码：475 / 488

页数：14

共 245 条

[1] WAVY LEAF1, an Ortholog of Arabidopsis HEN1, Regulates Shoot Development by Maintaining MicroRNA and Trans-Acting Small Interfering RNA Accumulation in Rice [J].

Abe, Masashi ;

Yoshikawa, Takanori ;

Nosaka, Misuzu ;

Sakakibara, Hitoshi ;

Sato, Yutaka ;

Nagato, Yasuo ;

Itoh, Jun-ichi .

PLANT PHYSIOLOGY, 2010, 154 (03) :1335-1346

[2] Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development [J].

Aboobaker, AA ;

Tomancak, P ;

Patel, N ;

Rubin, GM ;

Lai, EC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (50) :18017-18022

[3] Endogenous siRNA and miRNA targets identified by sequencing of the Arabidopsis degradome [J].

Addo-Quaye, Charles ;

Eshoo, Tifani W. ;

Bartel, David P. ;

Axtell, Michael J. .

CURRENT BIOLOGY, 2008, 18 (10) :758-762

[4] Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins [J].

Ameres, Stefan L. ;

Hung, Jui-Hung ;

Xu, Jia ;

Weng, Zhiping ;

Zamore, Phillip D. .

RNA, 2011, 17 (01) :54-63

[5] Target RNA-Directed Trimming and Tailing of Small Silencing RNAs [J].

Ameres, Stefan L. ;

Horwich, Michael D. ;

Hung, Jui-Hung ;

Xu, Jia ;

Ghildiyal, Megha ;

Weng, Zhiping ;

Zamore, Phillip D. .

SCIENCE, 2010, 328 (5985) :1534-1539

[6] Molecular basis for target RNA recognition and cleavage by human RISC [J].

Ameres, Stefan Ludwig ;

Martinez, Javier ;

Schroeder, Renee .

CELL, 2007, 130 (01) :101-112

[7] Vive la difference: biogenesis and evolution of microRNAs in plants and animals [J].

Axtell, Michael J. ;

Westholm, Jakub O. ;

Lai, Eric C. .

GENOME BIOLOGY, 2011, 12 (04)

[8] Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs [J].

Babiarz, Joshua E. ;

Ruby, J. Graham ;

Wang, Yangming ;

Bartel, David P. ;

Blelloch, Robert .

GENES & DEVELOPMENT, 2008, 22 (20) :2773-2785

[9] Kinetic Analysis Reveals the Fate of a MicroRNA following Target Regulation in Mammalian Cells [J].

Baccarini, Alessia ;

Chauhan, Hemangini ;

Gardner, Thomas J. ;

Jayaprakash, Anitha D. ;

Sachidanandam, Ravi ;

Brown, Brian D. .

CURRENT BIOLOGY, 2011, 21 (05) :369-376

[10] The impact of microRNAs on protein output [J].

Baek, Daehyun ;

Villen, Judit ;

Shin, Chanseok ;

Camargo, Fernando D. ;

Gygi, Steven P. ;

Bartel, David P. .

NATURE, 2008, 455 (7209) :64-U38

← 1 2 3 4 5 6 7 8 9 10 →