Biological properties of curcumin-cellular and molecular mechanisms of action

被引：594

作者：

Joe, B

Vijaykumar, M

Lokesh, BR

机构：

[1] Med Coll Ohio, Dept Physiol & Mol Med, Toledo, OH 43614 USA

[2] Johns Hopkins Med Inst, Dept Pathol, Immunol Lab, Baltimore, MD 21287 USA

[3] Cent Food Technol Res Inst, Dept Lipid Sci & Tradit Foods, Mysore 570013, Karnataka, India

来源：

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2004年 / 44卷 / 02期

关键词：

curcuminoid; spice; nutraceutical; food additive; inflammation; cancer;

D O I：

10.1080/10408690490424702

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Curcuminoids, a group of pheuolic compounds isolated from the roots of Curcuma longa (Zingiberaceae), exhibit a variety of beneficial effects on health and on events that help in preventing certain diseases. A vast majority of these studies were carried out with curcumin (diferuloyl methane), which is a major curcumiuoid. The most detailed studies using curcumin include anti-inflammatory, antioxidant, anticarcinogenic, antiviral, and antiinfectious activities. In addition, the wound healing and detoxifying properties of curcumin have also received considerable attention. As a result of extensive research on the therapeutic properties of curcumin, some understanding on the cellular; molecular, and biochemical mechanism of action of curcumin is emerging. These findings are summarized in this review.

引用

页码：97 / 111

页数：15

共 155 条

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[12] Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: Synthesis, biological evaluation, and molecular modeling [J].