Plasma noradrenaline and ageing: Effects of smoking habits

We tested the hypothesis that long-term smoking is responsible for increased plasma noradrenaline (NA) in elderly healthy subjects. Thirty-nine subjects were studied both at rest and during exercise: 10 young non-smokers (median age 24 years, range 21-33), 10 young smokers (30.5 years, 27-36), 10 elderly non-smokers (64 years, 52-75) and nine elderly smokers (62 years, 56-68). The young and elderly subjects had smoked for an average of 15 years and 46.8 years respectively. Plasma NA was significantly elevated in elderly long-term smokers compared with elderly non-smokers, young non-smokers and young smokers in both supine and sitting positions (supine: 1.06 +/- 0.24 vs. 0.71 +/- 0.22, 0.53 +/- 0.12, and 0.70 +/- 0.29 nmol L(-1) respectively; sitting. 3.01 +/- 0.83 vs. 2.07 +/- 0.77, 1.89 +/- 0.52 and 2.25 +/- 0.47 nmol L(-1) respectively). Plasma adrenaline did not differ among the groups. At submaximal exercise (60 W), plasma NA was significantly elevated in the elderly smokers compared with the other groups, owing to the elevated basal values. Increments in plasma NA at 60, 100 and 140 W were correlated with the relative exertion and not influenced by smoking. Plasma NA increased more in young subjects than in the elderly during maximal work load (21.7 +/- 8.0 vs. 13.4 +/- 54 nmol L(-1)) and correlated with the peak O-2 uptake. Total blood volume was not different among the four groups and correlated inversely with basal plasma NA. It is concluded that long-term smoking may contribute to increased basal plasma NA concentrations and probably also increased sympathetic nerve activity in elderly healthy subjects, whereas smoking has little if any effect on plasma NA responses induced by exercise. Interindividual variability in basal plasma NA concentrations may in part be explained by differences in blood volume.