Innate mechanisms of epithelial host defense: spotlight on intestine

被引：139

作者：

Hecht, G ^{[1
]}

机构：

[1] Univ Illinois, Dept Med, Sect Digest & Liver Dis, Chicago, IL 60612 USA

[2] W Side Vet Affairs Med Ctr, Chicago, IL 60612 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 1999年 / 277卷 / 03期

关键词：

chloride secretion; enteric pathogens; antimicrobial peptides; mucins; prostaglandins;

D O I：

10.1152/ajpcell.1999.277.3.C351

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Innate mechanisms of epithelial host defense: spotlight on intestine. Am. J. Physiol. 277 (Cell Physiol. 46): C351-C358, 1999. The single layer of epithelial cells lining the intestinal tract is charged with a most difficult task: protecting the underlying biological compartments from both the normal commensal flora that reside within the intestinal lumen as well as the uninvited pathogens. To such an end, the intestinal epithelial cells are equipped with a panoply of defense mechanisms, both constitutive and inducible. This review focuses only on those defense mechanisms that are initiated and executed by the intestinal epithelial cell. Fitting these strict criteria are three major categories of epithelial host defense: enhanced salt and water secretion, expression of antimicrobial proteins and peptides, and production of intestinal mucins. Each of these areas is discussed in this review.

引用

页码：C351 / C358

页数：8

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