The adoptive transfer of behavioral phenotype via the intestinal microbiota: experimental evidence and clinical implications

被引:146
作者
Collins, Stephen M. [1 ]
Kassam, Zain [1 ]
Bercik, Premysl [1 ]
机构
[1] McMaster Univ, Fac Hlth Sci, Dept Med, Farncombe Family Digest Hlth Res Inst, Hamilton, ON L8N 3Z5, Canada
基金
加拿大健康研究院;
关键词
CLOSTRIDIUM-DIFFICILE INFECTION; ANXIETY-LIKE BEHAVIOR; FECAL TRANSPLANTATION; GUT MICROBIOTA; MICE; BRAIN; DISEASE; DEPRESSION; DIVERSITY; INFANTIS;
D O I
10.1016/j.mib.2013.06.004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
There is growing interest in the ability of the intestinal microbiome to influence host function within and beyond the gastrointestinal tract. Here we review evidence of microbiome brain interactions in mice and focus on the ability to transfer behavioral traits between mouse strains using fecal microbiota transplantation (FMT). Transplantation alters brain chemistry and behavior in recipient ex-germ free mice, raising the possibility of using FMT for disorders of the central nervous system, and prompting caution in the selection of FMT donors for conditions that may include refractory Clostridium difficile infection, diabetes and inflammatory bowel disease in humans.
引用
收藏
页码:240 / 245
页数:6
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