B-type natriuretic peptide in pediatrics

被引：31

作者：

Davis, Gershwin K.

Barnforth, Fiona

Sarpal, Amrita

Dicke, Frank

Rabi, Yacov

Lyon, Martha E.

机构：

[1] Univ W Indies, Fac Med Sci, Dept Paraclin Sci, Champs Fleurs, Trinidad Tobago

[2] Univ Alberta, Dept Lab Med, Edmonton, AB, Canada

[3] Univ Calgary, Fac Med, Calgary, AB, Canada

[4] Univ Calgary, Dept Pediat, Calgary, AB T2N 1N4, Canada

[5] Calgary Lab Serv, Calgary, AB, Canada

[6] Univ Calgary, Dept Pathol & Lab Med, Calgary, AB T2N 1N4, Canada

[7] Univ Calgary, Dept Pharmacol, Calgary, AB T2N 1N4, Canada

来源：

CLINICAL BIOCHEMISTRY | 2006年 / 39卷 / 06期

关键词：

pediatrics; B-type natriuretic peptide; biomarker; heart failure;

D O I：

10.1016/j.clinbiochem.2005.12.004

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: There has been growing interest in the use of serum B-type natriuretic peptide (BNP) and the N-terminal segment of its prohormone (NT-proBNP) as biomarkers for cardiac disease. The aim of this review is to summarize the current state of knowledge regarding BNP and NT-proBNP measurement in the pediatric population. Design and methods: A computerized literature search on the National Library of Medicine was done and all articles including BNP and pediatrics were selected and discussed. Results: The data from several studies suggest that the measurement of BNP may be useful in diagnosing and managing pediatric heart failure, congenital heart disease, cardiac transplantation and patients on chemotherapy. There are difficulties in establishing appropriate reference ranges in children. Conclusion: There is insufficient evidence for the routine use of BNP or NT-proBNP. Further research to clearly define the clinical utility in the pediatric age group is eagerly anticipated. (c) 2005 The Canadian Society of Clinical Chemists. All rights reserved.

引用

页码：600 / 605

页数：6

共 52 条

[1] Vascular actions of natriuretic peptides - Cyclic GMP-dependent and -independent mechanisms [J].