Ca2+-activated Cl- channels:: a newly emerging anion transport family

被引:59
作者
Fuller, CM
Ji, HL
Tousson, A
Elble, RC
Pauli, BU
Benos, DJ
机构
[1] Univ Alabama, Dept Physiol & Biophys, Birmingham, AL 35294 USA
[2] Univ Alabama, Dept Cell Biol, Birmingham, AL 35294 USA
[3] Cornell Univ, Coll Vet Med, Dept Mol Med, Ithaca, NY 14853 USA
来源
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2001年 / 443卷 / Suppl 1期
关键词
calcium; cell adhesion; channels; CLCA family; cystic fibrosis; epithelia; electrophysiology; inositol polyphosphates;
D O I
10.1007/s004240100655
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
A new family of chloride transport proteins has recently emerged. These proteins have extensive homology to a protein previously isolated from bovine tracheal epithelium that acts as a Ca2+-sensitive Cl- channel (CaCC) when heterologously expressed or when reconstituted into planar lipid bilayers. Several new members of this family have been identified in human, murine, and bovine epithelia, in addition to some other tissues, and are associated with Ca2+-sensitive conductive chloride transport when heterologously expressed in Xenopus oocytes or HEK 293 cells. The expressed current is also sensitive to inhibitors such as DIDS and niflumic acid. In addition, at least one family member acts as an endothelial cell adhesion molecule. This emerging family may underlie the Ca2+-mediated Cl- conductance responsible for rescue of the cystic fibrosis (CF) knockout mouse from significant airway disease.
引用
收藏
页码:S107 / S110
页数:4
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