A highly effective phosphoramidite ligand for asymmetric allylic substitution

被引：259

作者：

Tissot-Croset, K ^{[1
]}

Polet, D ^{[1
]}

Alexakis, A ^{[1
]}

机构：

[1] Univ Geneva, Dept Chim Organ, CH-1211 Geneva 4, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 18期

关键词：

allylation; asymmetric catalysis; chiral auxiliaries; copper; iridium; magnesium;

D O I：

10.1002/anie.200353744

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Very high enantioselectivity has been achieved both in the copper-catalyzed alkylation of allylic substrates by Grignard and organozinc reagents and in the iridium-catalyzed animation of cinnamyl carbonate by employing a very efficient phosphoramidite ligand (see scheme).

引用

页码：2426 / 2428

页数：3

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