TXNIP Switches Tracks toward a Terminal UPR

被引：46

作者：

Anthony, Tracy G. ^{[2
]}

Wek, Ronald C. ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA

[2] Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USA

来源：

CELL METABOLISM | 2012年 / 16卷 / 02期

关键词：

NLRP3; INFLAMMASOME; STRESS; ACTIVATION; OBESITY;

D O I：

10.1016/j.cmet.2012.07.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell fate. In this issue, Lerner et al. (2012) and Oslowski et al. (2012) discover that thioredoxin-interacting protein (TXNIP) is a regulatory switch connecting the terminal unfolded protein response (UPR) and NLRP3 inflammasome to mediate beta cell death.

引用

页码：135 / 137

页数：3

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