Nanoparticles Functionalized with Ampicillin Destroy Multiple-Antibiotic-Resistant Isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and Methicillin-Resistant Staphylococcus aureus

被引：318

作者：

Brown, Ashley N. ^{[1
]}

Smith, Kathryn ^{[1
]}

Samuels, Tova A. ^{[2
]}

Lu, Jiangrui ^{[2
]}

Obare, Sherine O. ^{[2
]}

Scott, Maria E. ^{[1
]}

机构：

[1] Western Michigan Univ, Dept Biol Sci, Kalamazoo, MI 49008 USA

[2] Western Michigan Univ, Dept Chem, Kalamazoo, MI 49008 USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2012年 / 78卷 / 08期

基金：

美国国家科学基金会;

关键词：

PROTECTED GOLD NANOPARTICLES; GRAM-NEGATIVE BACTERIA; SILVER NANOPARTICLES; ESCHERICHIA-COLI; ANTIBACTERIAL ACTIVITY; GENERATION; INFECTIONS; ZEBRAFISH; TOXIN; MODEL;

D O I：

10.1128/AEM.06513-11

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

We show here that silver nanoparticles (AgNP) were intrinsically antibacterial, whereas gold nanoparticles (AuNP) were antimicrobial only when ampicillin was bound to their surfaces. Both AuNP and AgNP functionalized with ampicillin were effective broad-spectrum bactericides against Gram-negative and Gram-positive bacteria. Most importantly, when AuNP and AgNP were functionalized with ampicillin they became potent bactericidal agents with unique properties that subverted antibiotic resistance mechanisms of multiple-drug-resistant bacteria.

引用

页码：2768 / 2774

页数：7

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