Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

被引：176

作者：

Momose, Y

Murata, M

Kobayashi, K

Tachikawa, M

Nakabayashi, Y

Kanazawa, I

Toda, T

机构：

[1] Osaka Univ, Grad Sch Med, Dept Postgen & Dis, Div Funct Gen, Suita, Osaka 5650871, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Neurol, Tokyo, Japan

来源：

ANNALS OF NEUROLOGY | 2002年 / 51卷 / 01期

关键词：

D O I：

10.1002/ana.10079

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the SI8Y polymorphism of the UCH-L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease.

引用

页码：133 / 136

页数：4

共 22 条

[21] Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients
Wintermeyer, P
Krüger, R
Kuhn, W
Müller, T
Woitalla, D
Berg, D
Becker, G
Leroy, E
Polymeropoulos, M
Berger, K
Przuntek, H
Schöls, L
Epplen, JT
Riess, O
[J]. NEUROREPORT, 2000, 11 (10) : 2079 - 2082
[22] Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease
Zhang, J
Hattori, N
Leroy, E
Morris, HR
Kubo, SI
Kobayashi, T
Wood, NW
Polymeropoulos, MH
Mizuno, Y
[J]. PARKINSONISM & RELATED DISORDERS, 2000, 6 (04) : 195 - 197

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