Three new vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin). Bioactivity on osteoblast-like cells in culture

被引：80

作者：

Etcheverry, SB

Barrio, DA

Cortizo, AM

Williams, PAM

机构：

[1] Univ Nacl La Plata, Fac Cs Exactas, CEQUINOR, Ctr Quim Inorgan, RA-1900 La Plata, Argentina

[2] Natl Univ La Plata, Fac Cs Exactas, Catedra Bioquim Patol, RA-1900 La Plata, Argentina

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2002年 / 88卷 / 01期

关键词：

anti-inflammatory drugs; vanadyl complexes; spectroscopy; osteoblast proliferation;

D O I：

10.1016/S0162-0134(01)00368-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and spectral and magnetic characterization of VO2+ complexes with Ibuprofen (2-(4-isobutylphenyl)propionic acid), Naproxen (6-methoxy-alpha-methyl-2-naphthalene acetic acid) and Tolmetin (1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid) were studied. The complexes [VO(Ibu)(2)](.)5CH(3)OH, [VO(Nap)(2)](.)5CH(3)OH and [VO(Tol)(2)] were obtained from methanolic solutions under nitrogen atmosphere. The biological activities of these complexes on the proliferation of two osteoblast-like cells in culture (MCT3E1 and UMR106) were compared with that of the vanadyl(IV) cation. The complexes exhibited different effects depending on the concentration and the cellular type, while no effect was observed for their parent drugs. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：94 / 100

页数：7

共 40 条

[1] MONONUCLEAR AND BINUCLEAR COPPER(II) COMPLEXES OF THE ANTIINFLAMMATORY DRUG IBUPROFEN - SYNTHESIS, CHARACTERIZATION, AND CATECHOLASE-MIMETIC ACTIVITY [J].