Synthesis and characterization of a diruthenium-ibuprofenato complex -: Comparing its anti-inflammatory activity with that of a copper(II)-ibuprofenato complex

被引：61

作者：

Andrade, A

Namora, SF

Woisky, RG

Wiezel, G

Najjar, R

Sertié, JAA

Silva, DD

机构：

[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05513900 Sao Paulo, Brazil

[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Farmacol, BR-05589970 Sao Paulo, Brazil

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2000年 / 81卷 / 1-2期

基金：

巴西圣保罗研究基金会;

关键词：

diruthenium(II; III); copper(II); ibuprofen; anti-inflammatory; gastrotoxicity;

D O I：

10.1016/S0162-0134(00)00106-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ibuprofen complex of diruthenium(II,III) was prepared and characterized by electronic (UV-Vis) and vibrational (FTIR spectroscopies and thermogravimetry. The copper(II)-ibuprofenato complex was prepared by a different rc,ute from that described in the literature. Both complexes were tested in vivo for anti-inflammatory activity. Oral administration of the two complexes inhibited development of carrageenin-induced edema in rats, this inhibition being similar to that observed for oral administration of the parent drug (free ibuprofen). However, gastric irritation was lower as compared to that of ibuprofen. Diruthenium-ibuprofenato exhibited a protective effect at light intensity ulceration while the copper-ibuprofenato complex was more effective in the:protection of severe intensity ulceration. (C) 2000 Elsevier Science S.A. All rights reserved.

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页码：23 / 27

页数：5

相关论文

共 28 条

[1] Synthesis and characterization of copper-ibuprofenate complexes with 2,2'-bipyridine and 1,10-phenanthrolines and their hydrolytic activities in phosphate diester cleavage [J].

Abuhijleh, AL .

POLYHEDRON, 1997, 16 (04) :733-740

[2] MONONUCLEAR AND BINUCLEAR COPPER(II) COMPLEXES OF THE ANTIINFLAMMATORY DRUG IBUPROFEN - SYNTHESIS, CHARACTERIZATION, AND CATECHOLASE-MIMETIC ACTIVITY [J].

ABUHIJLEH, AL .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1994, 55 (04) :255-262

[3] Dinuclear paddle-wheel copper(II) carboxylates in the catalytic oxidation of carboxylic acids. Unusual polymeric chains found in the single-crystal x-ray structures of [tetrakis(mu-1-phenylcyclopropane-1-carboxylato-O,O')bis(ethanol-O)dicopper(II)] and catena-poly[[bis(mu-diphenylacetato-O:O')dicopper](mu(3)-diphenylacetato-1-O:2-O':1'-O')-(mu(3)-diphenylacetato-1-O:2-O':2'-O')] [J].

Agterberg, FPW ;

Kluit, HAJP ;

Driessen, WL ;

Oevering, H ;

Buijs, W ;

Lakin, MT ;

Spek, AL ;

Reedijk, J .

INORGANIC CHEMISTRY, 1997, 36 (20) :4321-4328

[4] PHARMACOLOGICAL ASSAY OF CASEARIA-SYLVESTRIS .1. PREVENTIVE ANTIULCER ACTIVITY AND TOXICITY OF THE LEAF CRUDE EXTRACT [J].

BASILE, AC ;

SERTIE, JAA ;

PANIZZA, S ;

OSHIRO, TT ;

AZZOLINI, CA .

JOURNAL OF ETHNOPHARMACOLOGY, 1990, 30 (02) :185-197

[5] ROLE OF COPPER IN PREVENTING GASTROINTESTINAL DAMAGE BY ACIDIC ANTI-INFLAMMATORY DRUGS [J].

BOYLE, E ;

FREEMAN, PC ;

GOUDIE, AC ;

MANGAN, FR ;

THOMSON, M .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1976, 28 (12) :865-868

[6] Preparation and crystal structure of a dimolybdenum(II) complex with the drug ibuprofen [J].

Cotton, FA ;

Silva, DDO .

INORGANICA CHIMICA ACTA, 1996, 249 (01) :57-61

[7] DIAGNOSIS OF THE NATURE OF CARBOXYLATE COORDINATION FROM THE DIRECTION OF SHIFTS OF CARBON OXYGEN STRETCHING FREQUENCIES [J].

DEACON, GB ;

HUBER, F ;

PHILLIPS, RJ .

INORGANICA CHIMICA ACTA-ARTICLES AND LETTERS, 1985, 104 (01) :41-45

[8] Anti-inflammatory drugs interacting with Zn(II), Cd(II) and Pt(II) metal ions [J].

Dendrinou-Samara, C ;

Tsotsou, G ;

Ekateriniadou, LV ;

Kortsaris, AH ;

Raptopoulou, CP ;

Terzis, A ;

Kyriakidis, DA ;

Kessissoglou, DP .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1998, 71 (3-4) :171-179

[9] SYNTHESIS AND MAGNETIC-PROPERTIES OF BIS[2-(4-ISOBUTYLPHENYL)PROPIONATO]COPPER(II) [J].

FRAZIER, DR ;

LYNCH, SK ;

CARLISLE, GO .

JOURNAL OF INORGANIC & NUCLEAR CHEMISTRY, 1981, 43 (11) :2747-2748

[10] USE OF CONDUCTIVITY MEASUREMENTS IN ORGANIC SOLVENTS FOR CHARACTERISATION OF COORDINATION COMPOUNDS [J].

GEARY, WJ .

COORDINATION CHEMISTRY REVIEWS, 1971, 7 (01) :81-&