Vinyl sulfones:: Inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus

被引：197

作者：

Frankel, BA

Bentley, M

Kruger, RG

McCafferty, DG ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Johnson Res Fdn, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 11期

关键词：

D O I：

10.1021/ja0390294

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several small molecule vinyl sulfones were found to exhibit irreversible time-dependent inhibition of the Staphylococcus aureus sortase SrtA in vitro. A representative of these compounds was shown to impair the ability of S. aureus bacteria to bind fibronectin-coated surfaces through in vivo inhibition of SrtA-mediated linkage of fibronectin to the cell surface. These data highlight the potential use of small molecule vinyl sulfones as chemotherapeutics to prevent adhesion to and colonization of host tissues during S. aureus infection. Copyright © 2004 American Chemical Society.

引用

页码：3404 / 3405

页数：2

共 28 条

[1] Bacterial virulence as a target for antimicrobial chemotherapy
Alksne, LE
Projan, SJ
[J]. CURRENT OPINION IN BIOTECHNOLOGY, 2000, 11 (06) : 625 - 636
[2] Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence
Bierne, H
Mazmanian, SK
Trost, M
Pucciarelli, MG
Liu, G
Dehoux, P
Jänsch, L
Garcia-del Portillo, F
Schneewind, O
Cossart, P
[J]. MOLECULAR MICROBIOLOGY, 2002, 43 (04) : 869 - 881
[3] Inactivation of the srtA gene in Streptococcus gordonii inhibits cell wall anchoring of surface proteins and decreases in vitro and in vivo adhesion
Bolken, TC
Franke, CA
Jones, KF
Zeller, GO
Jones, CH
Dutton, EK
Hruby, DE
[J]. INFECTION AND IMMUNITY, 2001, 69 (01) : 75 - 80
[4] CONNOLLY KM, 2003, J BIOL CHEM, V24, P24
[5] Comparison of adhesion of wound isolates of Staphylococcus aureus to immobilized proteins
Elgalai, I
Foster, HA
[J]. JOURNAL OF APPLIED MICROBIOLOGY, 2003, 94 (03) : 413 - 420
[6] CONSERVATION OF A HEXAPEPTIDE SEQUENCE IN THE ANCHOR REGION OF SURFACE-PROTEINS FROM GRAM-POSITIVE COCCI
FISCHETTI, VA
PANCHOLI, V
SCHNEEWIND, O
[J]. MOLECULAR MICROBIOLOGY, 1990, 4 (09) : 1603 - 1605
[7] The sortase SrtA of Listeria monocytogenes is involved in processing of internalin and in virulence
Garandeau, C
Réglier-Poupet, H
Dubail, L
Beretti, JL
Berche, P
Charbit, A
[J]. INFECTION AND IMMUNITY, 2002, 70 (03) : 1382 - 1390
[8] VINYLOGOUS AMINO-ACID ESTERS - A NEW CLASS OF INACTIVATORS FOR THIOL PROTEASES
HANZLIK, RP
THOMPSON, SA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (06) : 711 - 712
[9] Kinetic mechanism of Staphylococcus aureus sortase SrtA
Huang, XY
Aulabaugh, A
Ding, WD
Kapoor, B
Alksne, L
Tabei, K
Ellestad, G
[J]. BIOCHEMISTRY, 2003, 42 (38) : 11307 - 11315
[10] Inactivation of the srtA gene affects localization of surface proteins and decreases adhesion of Streptococcus pneumoniae to human pharyngeal cells in vitro
Kharat, AS
Tomasz, A
[J]. INFECTION AND IMMUNITY, 2003, 71 (05) : 2758 - 2765

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