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Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIV(mac)239

被引：133
作者：
Marcon, L
Choe, H
Martin, KA
Farzan, M
Ponath, PD
Wu, LJ
Newman, W
Gerard, N
Gerard, C
Sodroski, J
机构：
[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DEPT PATHOL,DIV HUMAN RETROVIROL,BOSTON,MA 02115
[2] CHILDRENS HOSP,INA SUE PERLMUTTER LAB,BOSTON,MA 02115
[3] BETH ISRAEL HOSP,DEPT MED,BOSTON,MA 02215
[4] BETH ISRAEL HOSP,DEPT PEDIAT,BOSTON,MA 02215
[5] HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115
[6] LEUKOSITE INC,CAMBRIDGE,MA 02142
[7] UNIV PADUA,SCH MED,INST MICROBIOL,I-35121 PADUA,ITALY
来源：
JOURNAL OF VIROLOGY | 1997年 / 71卷 / 03期
关键词：
D O I：
10.1128/JVI.71.3.2522-2527.1997
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We examined chemokine receptors for the ability to facilitate the infection of CD4-expressing cells by viruses containing the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIV(mac)239. Expression of either human or simian C-C chemokine receptor CCR5 allowed the SIV(mac)239 envelope glycoproteins to mediate virus entry and cell-to-cell fusion. Thus, distantly related immunodeficiency viruses such as SIV and the primary human immunodeficiency virus type 1 isolates can utilize CCR5 as an entry cofactor.
引用
收藏
页码：2522 / 2527
页数：6
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