Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms

被引：111

作者：

Altan-Bonnet, Nihal ^{[1
]}

Balla, Tamas ^{[2
]}

机构：

[1] Rutgers State Univ, Federated Dept Biol Sci, Host Pathogen Dynam Grp, Newark, NJ USA

[2] NICHD, Sect Mol Signal Transduct, NIH, Bethesda, MD USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2012年 / 37卷 / 07期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

C VIRUS-REPLICATION; PLASMA-MEMBRANE; LIPID KINASE; SECRETORY PATHWAY; YEAST HOMOLOG; III ALPHA; GOLGI; PROTEIN; BINDING; TRAFFICKING;

D O I：

10.1016/j.tibs.2012.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several RNA viruses have recently been shown to hijack members of the host phosphatidylinositol (PtdIns) 4-kinase (PI4K) family of enzymes. They use PI4K to generate membranes enriched in phosphatidylinositide 4-phosphate (PtdIns4P or PI4P) lipids, which can be used as replication platforms. Viral replication machinery is assembled on these platforms as a supramolecular complex and PtdIns4P lipids regulate viral RNA synthesis. This article highlights these recent studies on the regulation of viral RNA synthesis by PtdIns4P lipids. It explores the potential mechanisms by which PtdIns4P lipids can contribute to viral replication and discusses the therapeutic potential of developing antiviral molecules that target host PI4Ks as a form of panviral therapy.

引用

页码：293 / 302

页数：10

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