A phase I study of recombinant adenovirus vector-mediated intraperitoneal delivery of herpes simplex virus thymidine kinase (HSV-TK) gene and intravenous ganciclovir for previously treated ovarian and extraovarian cancer patients

被引：55

作者：

Alvarez, RD

Curiel, DT

机构：

[1] Division of Gynecologic Oncology, Old Hillman Building, Birmingham, AL 35233-7333

[2] Gene Therapy Program, Wallace Tumor Institute, Birmingham, AL 35233-7333

来源：

关键词：

RETROVIRAL VECTOR; BRAIN-TUMORS; CELLS; THERAPY; CHEMOTHERAPY;

D O I：

10.1089/hum.1997.8.5-597

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

[No abstract available]

引用

页码：597 / 613

页数：17

共 25 条

[11] Freeman SM, 1992, J CELL BIOCH F, V16F, P47
[12] FRIEDMANN T, 1992, CANCER, V70, P1810, DOI 10.1002/1097-0142(19920915)70:4+<1810::AID-CNCR2820701624>3.0.CO
[13] 2-3
[14] INHIBITION BY ACYCLOVIR OF CELL-GROWTH AND DNA-SYNTHESIS OF CELLS BIOCHEMICALLY TRANSFORMED WITH HERPESVIRUS GENETIC INFORMATION
FURMAN, PA
MCGUIRT, PV
KELLER, PM
FYFE, JA
ELION, GB
[J]. VIROLOGY, 1980, 102 (02) : 420 - 430
[15] JENKINS J, 1982, SURG GYNECOL OBSTET, V154, P858
[16] KARP JE, 1994, CANCER RES, V54, P653
[17] GENE-THERAPY - ADENOVIRUS VECTORS
KOZARSKY, KF
WILSON, JM
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1993, 3 (03) : 499 - 503
[18] A phase I trial of in vivo gene therapy with the herpes simplex thymidine kinase ganciclovir system for the treatment of refractory or recurrent ovarian cancer
Link, CJ
Moorman, D
Seregina, T
Levy, JP
Schabold, KJ
[J]. HUMAN GENE THERAPY, 1996, 7 (09) : 1161 - 1179
[19] RAM Z, 1993, CANCER RES, V53, P83
[20] GENE-THERAPY FOR CANCER
SIKORA, K
[J]. TRENDS IN BIOTECHNOLOGY, 1993, 11 (05) : 197 - 201