The design, synthesis and characterisation of channel-forming peptides

被引：16

作者：

Sanderson, JM ^{[1
]}

Yazdani, S ^{[1
]}

机构：

[1] Univ Sci Labs, Dept Chem, Durham DH1 3LE, England

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 10期

关键词：

D O I：

10.1039/b203046b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthetic peptides designed using criteria derived from statistical analyses of beta-barrel membrane proteins form channels in synthetic membranes at very low peptide:lipid ratios.

引用

页码：1154 / 1155

页数：2

共 12 条

[1] Understanding peptide interactions with the lipid bilayer: a guide to membrane protein engineering [J].

Bechinger, B .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2000, 4 (06) :639-644

[2] Folding of β-sheets in membranes:: Specificity and promiscuity in peptide model systems [J].

Bishop, CR ;

Walkenhorst, WF ;

Wimley, WC .

JOURNAL OF MOLECULAR BIOLOGY, 2001, 309 (04) :975-988

[3] THE MEASUREMENT OF TRANSMEMBRANE HELICES BY THE DECONVOLUTION OF CD SPECTRA OF MEMBRANE-PROTEINS - A REVIEW [J].

FASMAN, GD .

BIOPOLYMERS, 1995, 37 (05) :339-362

[4] Determinants of strand register in antiparallel β-sheets of proteins [J].

Hutchinson, EG ;

Sessions, RB ;

Thornton, JM ;

Woolfson, DN .

PROTEIN SCIENCE, 1998, 7 (11) :2287-2300

[5] A NOVEL, CONVENIENT, 3-DIMENSIONAL ORTHOGONAL STRATEGY FOR SOLID-PHASE SYNTHESIS OF CYCLIC-PEPTIDES [J].

KATES, SA ;

SOLE, NA ;

JOHNSON, CR ;

HUDSON, D ;

BARANY, G ;

ALBERICIO, F .

TETRAHEDRON LETTERS, 1993, 34 (10) :1549-1552

[6] Differential scanning calorimetry and X-ray diffraction studies of the specificity of the interaction of antimicrobial peptides with membrane-mimetic systems [J].

Lohner, K ;

Prenner, EJ .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1999, 1462 (1-2) :141-156

[7]

New R., 1990, Liposomes: a practical approach

[8] Designing stable β-hairpins:: Energetic contributions from cross-strand residues [J].

Russell, SJ ;

Cochran, AG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (50) :12600-12601

[9] CONFORMATION OF BETA-HAIRPINS IN PROTEIN STRUCTURES - A SYSTEMATIC CLASSIFICATION WITH APPLICATIONS TO MODELING BY HOMOLOGY, ELECTRON-DENSITY FITTING AND PROTEIN ENGINEERING [J].

SIBANDA, BL ;

BLUNDELL, TL ;

THORNTON, JM .

JOURNAL OF MOLECULAR BIOLOGY, 1989, 206 (04) :759-777

[10] Structure and assembly of β-barrel membrane proteins [J].

Tamm, LK ;

Arora, A ;

Kleinschmidt, JH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (35) :32399-32402

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