Ruthenium-catalyzed [2+2] cycloadditions of bicyclic alkenes and ynamides

被引：46

作者：

Villeneuve, K ^{[1
]}

Riddell, N ^{[1
]}

Tam, W ^{[1
]}

机构：

[1] Univ Guelph, Dept Chem, Guelph Waterloo Ctr Grad Work Chem & Biochem, Guelph, ON N1G 2W1, Canada

来源：

TETRAHEDRON | 2006年 / 62卷 / 16期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ynamines; cycloaddition; amidation;

D O I：

10.1016/j.tet.2005.11.081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ruthenium-catalyzed [2+2] cycloadditions between bicyclic alkenes and ynamides were investigated. The ynamide moiety was found to be compatible with the ruthenium-catalyzed cycloaddition conditions giving the corresponding cyclobutene cycloadducts in moderate to good yields (up to 97%). Diastereoselective cycloaddition utilizing chiral cyclic ynamides were also examined and a low to moderate level of asymmetric induction was observed. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3823 / 3836

页数：14

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