Palladium-catalyzed Suzuki-Miyaura coupling reactions involving β,β-dihaloenamides:: Application to the synthesis of disubstituted ynamides

被引：47

作者：

Couty, S ^{[1
]}

Barbazanges, M ^{[1
]}

Meyer, C ^{[1
]}

Cossy, J ^{[1
]}

机构：

[1] Ecole Super Phys & Chim Ind Ville Paris, Assoc CNRS, Chim Organ Lab, F-75231 Paris, France

来源：

SYNLETT | 2005年 / 06期

关键词：

cross-coupling; palladium; enamides; eliminations; ynamides;

D O I：

10.1055/s-2005-864821

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta,beta-Dihaloenamides can be successfully involved in palladium-catalyzed Suzuki-Miyaura coupling reactions. Whereas the resulting trisubstituted (Z)-beta-bromoenamides could participate in a second cross-coupling leading to beta, beta-disubstituted enamides, the (Z)-beta-chloroenamides have been converted to disubstituted ynamides by an E-2 elimination.

引用

页码：905 / 910

页数：6

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