Flow injection chemiluminescence determination of captopril based on its enhancing effect on the luminol-ferricyanide/ferrocyanide reaction

被引：31

作者：

Du, JX ^{[1
]}

Li, YH ^{[1
]}

Lu, JR ^{[1
]}

机构：

[1] Shaanxi Normal Univ, Sch Chem & Mat Sci, Dept Chem, Xian 710062, Peoples R China

来源：

LUMINESCENCE | 2002年 / 17卷 / 03期

关键词：

chemiluminescence; flow injection; captopril; pharmaceutical analysis;

D O I：

10.1002/bio.685

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new flow injection chemiluminescence method is described for the determination of captopril. It is based on the enhancing effect of captopril on the chemiluminescence reaction of luminol with potassium ferricyanide in alkaline solution in the presence of potassium ferrocyanide. The method allows the determination of captopril over 0.1-40 mug/mL range, with a relative standard deviation (SD) of 1.0% for the determination of 0.5 mug/mL captopril solution in I I repeated measurements. The method was satisfactorily applied to the determination of captopril in commercial captopril tablets. The possible reaction mechanism is also discussed briefly. Copyright (C) 2002 John Wiley Sons. Ltd.

引用

页码：165 / 167

页数：3

共 14 条

[1] LUMINOL ASSAY FOR SUPEROXIDE-DISMUTASE [J].

BENSINGER, RE ;

JOHNSON, CM .

ANALYTICAL BIOCHEMISTRY, 1981, 116 (01) :142-145

[2]

CHEN Q, 1993, CHINESE MED STUDY ME, P953

[3] Determination of pharmaceutical thiols by liquid chromatography with electrochemical detection: Use of an electrode with a conductive carbon cement matrix, chemically modified with cobalt phthalocyanine [J].

Favaro, G ;

Fiorani, M .

ANALYTICA CHIMICA ACTA, 1996, 332 (2-3) :249-255

[4] Application of principal component regression to the determination of Captopril by differential pulse polarography with no prior removal of dissolved oxygen [J].

Fraga, JMG ;

Abizanda, AIJ ;

Moreno, FJ ;

Leon, JJA .

TALANTA, 1998, 46 (01) :75-82

[5] Determination of captopril and its degradation products by capillary electrophoresis [J].

Hillaert, S ;

Van den Bossche, W .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1999, 21 (01) :65-73

[6]

Karlicek R, 1998, PHARMAZIE, V53, P549

[7] Chemiluminescence of β-lactam antibiotics based on the luminol reaction [J].

Kubo, H ;

Saitoh, M ;

Murase, S ;

Inomata, T ;

Yoshimura, Y ;

Nakazawa, H .

ANALYTICA CHIMICA ACTA, 1999, 389 (1-3) :89-94

[8] Chemiluminescence flow injection analysis of reducing agents based on the luminol reaction [J].

Kubo, H ;

Toriba, A .

ANALYTICA CHIMICA ACTA, 1997, 353 (2-3) :345-349

[9]

Liu C, 1998, Se Pu, V16, P82

[10]

SHEN JM, 1989, PHARM STRUCTURE REAG, P541

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