学术探索
学术期刊
新闻热点
数据分析
智能评审

Cardiac mechanosensitivity and stretch-activated ion channels

被引：21
作者：
Bett, GCL
Sachs, F
机构：
[1] Department of Biophysical Sciences, State University of New York, Buffalo
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 1997年 / 7卷 / 01期
关键词：
D O I：
10.1016/S1050-1738(96)00119-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Mechanosensitivity is a ubiquitous property of cells, and mechanosensitive ion channels (MSCs) are hypothesized to be the transducers. In the heart MSCs are likely to account for changes in beating rate as a function of filling and for initiating stretch-induced arrhythmias (for example, following a myocardial infarction). Pharmacological agents that affect MSCs may provide a new class of antiarrhythmic drugs. (C) 1997, Elsevier Science Inc.
引用
收藏
页码：4 / 8
页数：5
相关论文
共 65 条
  • [1] MECHANOELECTRICAL FEEDBACK IN CARDIAC MYOCYTES FROM STRETCH-ACTIVATED ION CHANNELS
    AKAY, M
    CRAELIUS, W
    [J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1993, 40 (08) : 811 - 816
  • [2] PROGNOSIS OF PATIENTS WITH SUSTAINED VENTRICULAR-TACHYCARDIA AND OF SURVIVORS OF CARDIAC-ARREST NOT INDUCIBLE BY PROGRAMMED STIMULATION
    ANDRESEN, D
    STEINBECK, G
    BRUGGEMANN, T
    HABERL, R
    FINK, L
    SCHRODER, R
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1992, 70 (15) : 1250 - 1254
  • [3] Bainbridge FA, 1915, J PHYSIOL-LONDON, V50, P65
  • [4] Bett G. C. L., 1996, Biophysical Journal, V70, pA346
  • [5] ELECTROPHYSIOLOGICAL EFFECT OF VOLUME LOAD IN ISOLATED CANINE HEARTS
    CALKINS, H
    MAUGHAN, WL
    KASS, DA
    SAGAWA, K
    LEVINE, JH
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (06): : H1697 - H1706
  • [6] Ca2+ uptake in GH(3) cells during hypotonic swelling: The sensory role of stretch-activated ion channels
    Chen, Y
    Simasko, SM
    Niggel, J
    Sigurdson, WJ
    Sachs, F
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1996, 270 (06): : C1790 - C1798
  • [7] DELUNA AB, 1990, REV PORT CARDIOL, V9, P473
  • [8] MECHANICALLY INDUCED ACTION-POTENTIAL CHANGES AND ARRHYTHMIA IN ISOLATED AND INSITU CANINE HEARTS
    FRANZ, MR
    BURKHOFF, D
    YUE, DT
    SAGAWA, K
    [J]. CARDIOVASCULAR RESEARCH, 1989, 23 (03) : 213 - 223
  • [9] ELECTROPHYSIOLOGICAL EFFECTS OF MYOCARDIAL STRETCH AND MECHANICAL DETERMINANTS OF STRETCH-ACTIVATED ARRHYTHMIAS
    FRANZ, MR
    CIMA, R
    WANG, D
    PROFITT, D
    KURZ, R
    [J]. CIRCULATION, 1992, 86 (03) : 968 - 978
  • [10] FRANZ MR, 1992, CIRCULATION, V86, P1663
1234567