Cardiac mechanosensitivity and stretch-activated ion channels

被引：21

作者：

Bett, GCL

Sachs, F

机构：

[1] Department of Biophysical Sciences, State University of New York, Buffalo

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S1050-1738(96)00119-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mechanosensitivity is a ubiquitous property of cells, and mechanosensitive ion channels (MSCs) are hypothesized to be the transducers. In the heart MSCs are likely to account for changes in beating rate as a function of filling and for initiating stretch-induced arrhythmias (for example, following a myocardial infarction). Pharmacological agents that affect MSCs may provide a new class of antiarrhythmic drugs. (C) 1997, Elsevier Science Inc.

引用

页码：4 / 8

页数：5

共 65 条

[21] PURIFICATION AND FUNCTIONAL RECONSTITUTION OF THE RECOMBINANT LARGE MECHANOSENSITIVE ION-CHANNEL (MSCL) OF ESCHERICHIA-COLI
HASE, CC
LEDAIN, AC
MARTINAC, B
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (31) : 18329 - 18334
[22] STRETCH-INACTIVATED CATIONIC CHANNELS IN SINGLE SMOOTH-MUSCLE CELLS
HISADA, T
WALSH, JV
SINGER, JJ
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1993, 422 (04): : 393 - 396
[23] Hu Hai, 1996, Biophysical Journal, V70, pA347
[24] Hu Hai, 1995, Biophysical Journal, V68, pA393
[25] GENE INTERACTIONS AFFECTING MECHANOSENSORY TRANSDUCTION IN CAENORHABDITIS-ELEGANS
HUANG, MX
CHALFIE, M
[J]. NATURE, 1994, 367 (6462) : 467 - 470
[26] LOAD RESPONSIVENESS OF PROTEIN-SYNTHESIS IN ADULT MAMMALIAN MYOCARDIUM - ROLE OF CARDIAC DEFORMATION LINKED TO SODIUM INFLUX
KENT, RL
HOOBER, JK
COOPER, G
[J]. CIRCULATION RESEARCH, 1989, 64 (01) : 74 - 85
[27] INTRACELLULAR SIGNALING PATHWAYS IN CARDIAC MYOCYTES INDUCED BY MECHANICAL-STRESS
KOMURO, I
YAZAKI, Y
[J]. TRENDS IN CARDIOVASCULAR MEDICINE, 1994, 4 (03) : 117 - 121
[28] THE STRETCH-ACTIVATED ION-CHANNEL BLOCKER GADOLINIUM ALSO BLOCKS L-TYPE CALCIUM CHANNELS IN ISOLATED VENTRICULAR MYOCYTES OF THE GUINEA-PIG
LACAMPAGNE, A
GANNIER, F
ARGIBAY, J
GARNIER, D
LEGUENNEC, JY
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1994, 1191 (01): : 205 - 208
[29] BLOCK OF STRETCH-ACTIVATED ATRIAL-NATRIURETIC-PEPTIDE SECRETION BY GADOLINIUM IN ISOLATED RAT ATRIUM
LAINE, M
ARJAMAA, O
VUOLTEENAHO, O
RUSKOAHO, H
WECKSTROM, M
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1994, 480 : 553 - 561
[30] IONIC EFFECTS ON AMILORIDE BLOCK OF THE MECHANOSENSITIVE CHANNEL IN XENOPUS OOCYTES
LANE, JW
MCBRIDE, DW
HAMILL, OP
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 (01) : 116 - 119

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