Mechanism of response enhancement in evaporative light scattering detection with the addition of triethylamine and formic acid

被引：44

作者：

Deschamps, FS ^{[1
]}

Baillet, A ^{[1
]}

Chaminade, P ^{[1
]}

机构：

[1] Fac Pharm Chatenay Malabry, Chim Analyt Lab, Grp Chim Analyt Paris Sud, F-92296 Chatenay Malabry, France

来源：

ANALYST | 2002年 / 127卷 / 01期

关键词：

D O I：

10.1039/b108810f

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Triethylamine with an equimolar amount of formic acid added to the mobile phase provides an enhancement of the evaporative light scattering detector (ELSD) response. After characterization of the influence of various parameters on the ELSD response, a sequential strategy was defined to elucidate this response enhancement. The response enhancement was more marked at low mobile phase flow rate, and was highly dependent on solutes and solvents. The influence of drift tube temperature on response enhancement with various solutes demonstrated that triethylamine and formic acid mainly act as mass amplifiers by the inclusion of triethylamine-formic acid clusters inside the droplets.

引用

页码：35 / 41

页数：7

共 20 条

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