Bioactive brominated metabolites from the Red Sea sponge Suberea mollis

被引：62

作者：

Abou-Shoer, Mohamed I. ^{[2
]}

Shaala, Lamiaa A. ^{[1
]}

Youssef, Diaa T. A. ^{[1
]}

Badr, Jihan M. ^{[1
]}

Habib, Abdel-Azim M. ^{[2
]}

机构：

[1] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt

[2] Univ Alexandria, Dept Pharmacognosy, Fac Pharm, Alexandria 21521, Egypt

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 08期

关键词：

D O I：

10.1021/np800142n

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Reinvestigation of the Red Sea sponge Suberea mollis afforded two new bromotyrosine-derived alkaloids. subereamollines A (1) and B (2), two new brominated phenolic compounds, subereaphenols B (7) and C (9), and the known compounds aerothionin (3), homoaerothionin (4), 11, 19-dideoxyfistularin-3 (5). aeroplysinin-1 (6). and aeroplysinin-2 (8). The structure determination of the isolated compounds was assigned using one- and two-dimensional NMR spectra and HRFABMS data. The antimicrobial and antioxidant activities of the isolated compounds have been evaluated. Aeroplysinin-1 displayed significant antimicrobial activity against S. aureus, P. aerugenosa, and K. pneumoniae. The isolated compounds were examined for their antioxidant activity using a 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) solution-based chemical assay. Among the tested compounds, only subereaphenols B and C displayed a significant effect.

引用

页码：1464 / 1467

页数：4

共 20 条

[1] 11-OXOAEROTHIONIN - A CYTOTOXIC ANTITUMOR BROMOTYROSINE-DERIVED ALKALOID FROM THE CARIBBEAN MARINE SPONGE APLYSINA-LACUNOSA [J].

ACOSTA, AL ;

RODRIGUEZ, AD .

JOURNAL OF NATURAL PRODUCTS, 1992, 55 (07) :1007-1012

[2] CHEMISTRY OF VERONGIDA SPONGES .1. CONSTITUENTS OF THE CARIBBEAN SPONGE PSEUDOCERATINA-CRASSA [J].

ALBRIZIO, S ;

CIMINIELLO, P ;

FATTORUSSO, E ;

MAGNO, S ;

PANSINI, M .

TETRAHEDRON, 1994, 50 (03) :783-788

[3]

ANDERSEN R J, 1973, Tetrahedron Letters, V14, P1175, DOI 10.1016/S0040-4039(01)95788-0

[4] Lihouidine, a novel spiro polycyclic aromatic alkaloid from the marine sponge Suberea n. sp (Aplysinellidae, Verongida) [J].

Bowden, BF ;

McCool, BJ ;

Willis, RH .

JOURNAL OF ORGANIC CHEMISTRY, 2004, 69 (23) :7791-7793

[5] Probing sponge-derived terpenoids for human 15-lipoxygenase inhibitors [J].

Carroll, J ;

Jonsson, EN ;

Ebel, R ;

Hartman, MS ;

Holman, TR ;

Crews, P .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (21) :6847-6851

[6] CHEMISTRY OF VERONGIDA SPONGES .2. CONSTITUENTS OF THE CARIBBEAN SPONGE APLYSINA-FISTULARIS FORMA FULVA [J].

CIMINIELLO, P ;

COSTANTINO, V ;

FATTORUSSO, E ;

MAGNO, S ;

MANGONI, A ;

PANSINI, M .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (06) :705-712

[7]

Debitus C, 1998, J MAR BIOTECHNOL, V6, P136

[8] Calafianin, a bromotyrosine derivative from the marine sponge Aplysina gerardogreeni [J].

Encarnación, RD ;

Sandoval, E ;

Malmstrom, J ;

Christophersen, C .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (06) :874-875

[9] FISTULARIN-3 AND 11-KETOFISTULARIN-3 - FELINE LEUKEMIA-VIRUS ACTIVE BROMOTYROSINE METABOLITES FROM THE MARINE SPONGE APLYSINA-ARCHERI [J].

GUNASEKERA, SP ;

CROSS, SS .

JOURNAL OF NATURAL PRODUCTS, 1992, 55 (04) :509-512

[10] Ma'edamines A and B, cytotoxic bromotyrosine alkaloids with a unique 2(1H)pyrazinone ring from sponge Suberea sp. [J].

Hirano, K ;

Kubota, T ;

Tsuda, M ;

Watanabe, K ;

Fromont, J ;

Kobayashi, J .

TETRAHEDRON, 2000, 56 (41) :8107-8110

← 1 2 →