Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis

被引：113

作者：

Gardi, C. ^{[1
,2
]}

Bauerova, K. ^{[3
,4
]}

Stringa, B. ^{[2
]}

Kuncirova, V. ^{[3
]}

Slovak, L. ^{[3
]}

Ponist, S. ^{[3
]}

Drafi, F. ^{[3
]}

Bezakova, L. ^{[4
]}

Tedesco, I. ^{[1
]}

Acquaviva, A. ^{[2
]}

Bilotto, S. ^{[1
]}

Russo, G. L. ^{[1
]}

机构：

[1] CNR, Inst Food Sci, I-83100 Avellino, Italy

[2] Univ Siena, Dept Mol & Dev Med, I-53100 Siena, Italy

[3] Slovak Acad Sci, Inst Expt Pharmacol & Toxicol, SK-84104 Bratislava, Slovakia

[4] Comenius Univ, Fac Pharm, Bratislava, Slovakia

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2015年 / 583卷

关键词：

Quercetin; Adjuvant arthritis; NF-kappa B; ERK pathway; Inflammation; Oxidative stress; NF-KAPPA-B; NITRIC-OXIDE PRODUCTION; NECROSIS-FACTOR-ALPHA; RHEUMATOID-ARTHRITIS; OXIDATIVE STRESS; FLAVONOID QUERCETIN; SIGNALING PATHWAY; HEME OXYGENASE-1; PROTEIN-KINASES; P38; MAPK;

D O I：

10.1016/j.abb.2015.08.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Novel therapies for rheumatoid arthritis also include the use of naturally occurring compounds possessing antioxidant properties. In the present work, the effects of oral administration of quercetin were investigated in a rat model of adjuvant arthritis. Arthritis was induced by a single intradermal injection of heat-inactivated Mycobacterium butyricum in incomplete Freund's adjuvant. The experimental groups were treated with an oral daily dose of 150 mg/kg b.w. of quercetin for 28 days. Results indicated that quercetin was able to ameliorate all markers of inflammation and oxidative stress measured. Quercetin lowered levels of interleukin-1 beta, C-reactive protein, and monocyte chemotactic protein-1 and restored plasma antioxidant capacity. In addition, quercetin inhibited the enzymatic activity of pro-inflammatory 12/15-lipoxygenase in lung and liver and increased the expression of heme oxygenase-1 in joint and lung of arthritic rats. Finally, quercetin inhibited the 2-fold increase of NF-kappa B activity observed in lung, liver and joint after induction of arthritis. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：150 / 157

页数：8

共 79 条

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