Sex hormones and hypertension

被引:428
作者
Dubey, RK
Oparil, S
Imthurn, B
Jackson, EK
机构
[1] Univ Zurich Hosp, Clin Endocrinol, Dept Gynecol & Obstet, CH-8051 Zurich, Switzerland
[2] Univ Pittsburgh, Med Ctr, Ctr Clin Pharmacol, Pittsburgh, PA 15213 USA
[3] Univ Pittsburgh, Med Ctr, Dept Med, Pittsburgh, PA 15213 USA
[4] Univ Pittsburgh, Med Ctr, Dept Pharmacol, Pittsburgh, PA 15213 USA
[5] Univ Alabama Birmingham, Vasc Biol & Hypertens Program, Birmingham, AL 35294 USA
关键词
blood pressure; endothelial function; gender; growth factors; hypertension; smooth muscle;
D O I
10.1016/S0008-6363(01)00527-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Gender has an important influence on blood pressure, with premenopausal women having a lower arterial blood pressure than age-matched men. Compared with premenopausal women, postmenopausal women have higher blood pressures, suggesting that ovarian hormones may modulate blood pressure. However, whether sex hormones are responsible for the observed gender-associated differences in arterial blood pressure and whether ovarian hormones account for differences in blood pressure in premenopausal versus postmenopausal women remains unclear. In this review, we provide a discussion of the potential blood pressure regulating effects of female and male sex hormones, as well as the cellular, biochemical and molecular mechanisms by which sex hormones may modify the effects of hypertension on the cardiovascular system. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:688 / 708
页数:21
相关论文
共 244 条
[31]   SEXUAL DIMORPHISM OF BLOOD-PRESSURE IN SPONTANEOUSLY HYPERTENSIVE RATS IS ANDROGEN DEPENDENT [J].
CHEN, YF ;
MENG, QC .
LIFE SCIENCES, 1991, 48 (01) :85-96
[32]   ANDROGEN-DEPENDENT ANGIOTENSINOGEN AND RENIN MESSENGER-RNA EXPRESSION IN HYPERTENSIVE RATS [J].
CHEN, YF ;
NAFTILAN, AJ ;
OPARIL, S .
HYPERTENSION, 1992, 19 (05) :456-463
[33]   Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen [J].
Chen, Z ;
Yuhanna, IS ;
Galcheva-Gargova, Z ;
Karas, RH ;
Mendelsohn, RE ;
Shaul, PW .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (03) :401-406
[34]   Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo [J].
Chou, TM ;
Sudhir, K ;
Hutchison, SJ ;
Ko, E ;
Amidon, TM ;
Collins, P ;
Chatterjee, K .
CIRCULATION, 1996, 94 (10) :2614-2619
[35]   TESTOSTERONE-INDUCED HYPERTENSION IN RAT [J].
COLBY, HD ;
SKELTON, FR ;
BROWNIE, AC .
ENDOCRINOLOGY, 1970, 86 (05) :1093-&
[36]   NITRIC-OXIDE ACCOUNTS FOR DOSE-DEPENDENT ESTROGEN-MEDIATED CORONARY RELAXATION AFTER ACUTE ESTROGEN WITHDRAWAL [J].
COLLINS, P ;
SHAY, J ;
JIANG, CW ;
MOSS, J .
CIRCULATION, 1994, 90 (04) :1964-1968
[37]   17-BETA-ESTRADIOL ATTENUATES ACETYLCHOLINE-INDUCED CORONARY ARTERIAL CONSTRICTION IN WOMEN BUT NOT MEN WITH CORONARY HEART-DISEASE [J].
COLLINS, P ;
ROSANO, GMC ;
SARREL, PM ;
ULRICH, L ;
ADAMOPOULOS, S ;
BEALE, CM ;
MCNEILL, JG ;
POOLEWILSON, PA .
CIRCULATION, 1995, 92 (01) :24-30
[38]   ESTROGENS AND HYPERTENSION - EFFECT OF DISCONTINUING ESTROGENS ON BLOOD-PRESSURE, EXCHANGEABLE SODIUM, AND RENIN-ALDOSTERONE SYSTEM [J].
CRANE, MG ;
HARRIS, JJ .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1978, 276 (01) :33-55
[39]   HYPERTENSION, ORAL CONTRACEPTIVE AGENTS, AND CONJUGATED ESTROGENS [J].
CRANE, MG ;
HARRIS, JJ ;
WINSOR, W .
ANNALS OF INTERNAL MEDICINE, 1971, 74 (01) :13-+
[40]   Antagonistic effects of 17β-estradiol, progesterone, and testosterone on Ca2+ entry mechanisms of coronary vasoconstriction [J].
Crews, JK ;
Khalil, RA .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (04) :1034-1040