Paediatric anaphylaxis: a 5 year retrospective review

被引:169
作者
de Silva, I. L. [1 ]
Mehr, S. S. [1 ]
Tey, D. [1 ]
Tang, M. L. K. [1 ]
机构
[1] Royal Childrens Hosp, Dept Allergy & Immunol, Melbourne, Vic, Australia
关键词
anaphylaxis; child; teenager;
D O I
10.1111/j.1398-9995.2008.01719.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Objective: To describe the demographic characteristics, clinical features, causative agents, settings and administered therapy in children presenting with anaphylaxis. Methods: This was a retrospective case note study of children presenting with anaphylaxis over a 5-year period to the Emergency Department (ED) at the Royal Children's Hospital, Melbourne. Results: One-hundred and twenty-three cases of anaphylaxis in 117 patients were included. There was one death. The median age of presentation was 2.4 years. Home was the most common setting (48%) and food (85%) the most common trigger. Peanut (18%) and cashew nut (13%) were the most common cause of anaphylaxis. The median time from exposure to anaphylaxis for all identifiable agents was 10 min. The median time from onset to therapy was 40 min. Respiratory features were the principal presenting symptoms (97%). Seventeen per cent of subjects had experienced anaphylaxis previously. Conclusions: This is the largest study of childhood anaphylaxis reported. Major findings are that most children presenting to the ED with anaphylaxis are first-time anaphylactic reactions and the time to administration of therapy is often significantly delayed. Most reactions occurred in the home. Peanut and cashew nut were the most common causes of anaphylaxis in this study population, suggesting that triggers for anaphylaxis in children have not changed significantly over the last decade.
引用
收藏
页码:1071 / 1076
页数:6
相关论文
共 35 条
[1]  
Alves B, 2001, ARCH DIS CHILD, V85, P349
[2]   ASCIA guidelines for prevention of food anaphylactic reactions in schools, preschools and child-care centres [J].
Baumgart, K ;
Brown, S ;
Gold, M ;
Kemp, A ;
Loblay, R ;
Loh, R ;
Mitrou, D ;
Mullins, R ;
Peake, J ;
Ruhno, J ;
Said, M ;
Sinclair, J ;
Smith, V ;
Smith, W ;
Solley, G ;
Soutter, V ;
Tang, M ;
Ziegler, J .
JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 2004, 40 (12) :669-671
[3]  
Bellou Abdelouahab, 2003, Emerg Med (Fremantle), V15, P341, DOI 10.1046/j.1442-2026.2003.00472.x
[4]   Further fatalities caused by anaphylactic reactions to food, 2001-2006 [J].
Bock, S. Allan ;
Munoz-Furlong, Anne ;
Sampson, Hugh A. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (04) :1016-1018
[5]   Fatalities due to anaphylactic reactions to foods [J].
Bock, SA ;
Muñoz-Furlong, A ;
Sampson, HA .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (01) :191-193
[6]   Parent reported allergy and anaphylaxis in 4173 South Australian children [J].
Boros, CA ;
Kay, D ;
Gold, MS .
JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 2000, 36 (01) :36-40
[7]   Paediatric emergency department anaphylaxis: different patterns from adults [J].
Braganza, SC ;
Acworth, JP ;
Mckinnon, DRL ;
Peake, JE ;
Brown, AFT .
ARCHIVES OF DISEASE IN CHILDHOOD, 2006, 91 (02) :159-163
[8]   Emergency department anaphylaxis: A review of 142 patients in a single year [J].
Brown, AFT ;
McKinnon, D .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (05) :861-866
[9]   Bronchospasm and laryngeal stridor as an adverse effect of oxytocin treatment [J].
Cabestrero, D ;
Pérez-Paredes, C ;
Fernández-Cid, R ;
Arribas, MA .
CRITICAL CARE, 2003, 7 (05) :392-392
[10]   Clinical features of acute anaphylaxis in patients admitted to a university hospital: an 11-year retrospective review (1985-1996) [J].
Cianferoni, A ;
Novembre, E ;
Mugnaini, L ;
Lombardi, E ;
Bernardini, R ;
Pucci, N ;
Vierucci, A .
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2001, 87 (01) :27-32