Optimal dose of hepatobiliary contrast agent for MR cholangiography: Experimental study in rats

被引：5

作者：

Hirohashi, S ^{[1
]}

Hirohashi, R ^{[1
]}

Uchida, H ^{[1
]}

Kitano, S ^{[1
]}

Akira, M ^{[1
]}

Ono, W ^{[1
]}

Ohishi, H ^{[1
]}

Kato, N ^{[1
]}

Takahashi, M ^{[1
]}

Miyazawa, T ^{[1
]}

机构：

[1] Nara Med Univ, Dept Radiol, Kahihara, Nara, Japan

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1998年 / 8卷 / 04期

关键词：

hepatobiliary contrast agent; MR cholangiography; MRI; liver;

D O I：

10.1002/jmri.1880080414

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The purpose of this study is to clarify the optimal dose of gadolinium-ethoxybenzyl-diethylenetriaminepenta- acetic acid (Gd-EOB-DTPA) for cholangiography in conventional T1-weighted imaging. We divided 30 rats into three dose groups (3, 10, and 30 mu mol/kg). For the in vitro study, we collected bile and measured the concentration of gadolinium In bile after Gd-EOB-DTPA injection. T1-weighted images of the collected bile were obtained for measurement of signal intensity. For the in vivo study, we obtained T1-weighted images before and after injection and evaluated bile duct/liver contrast by the signal intensity ratio and visual assessment of the images. The gadolinium concentration had an early peak; however, the signal intensity of the bile had a later peak because of the high gadolinium concentration during the early phase, which induced a T2-shortening effect. Optimal bile duct/liver contrast was obtained in the 10-mu mol/kg groups at all time points, We conclude that the optimal dose of Gd-EOB-DTPA for MR cholangiography in rats is 10 mu mol/kg, one-third of the dose used in liver imaging.

引用

页码：847 / 852

页数：6

共 18 条

[1] Gadolinium-ethoxybenzyl-DTPA as a hepatobiliary contrast agent for use in MR cholangiography: Results of an in vivo phase-I clinical evaluation [J].