Comparison of cytomorphological and architectural heterogeneity in mammographically-detected ductal carcinoma in situ

被引:12
作者
Harrison, M
Coyne, JD
Gorey, T
Dervan, PA
机构
[1] NATL UNIV IRELAND UNIV COLL DUBLIN,MATER MISERICORDIAE HOSP,DEPT PATHOL,DUBLIN 7,IRELAND
[2] NATL UNIV IRELAND UNIV COLL DUBLIN,MATER MISERICORDIAE HOSP,DEPT SURG,DUBLIN 7,IRELAND
[3] WITHINGTON HOSP,DEPT PATHOL,MANCHESTER,LANCS,ENGLAND
关键词
ductal carcinoma in situ; heterogeneity; cytomorphology; classification;
D O I
10.1046/j.1365-2559.1996.322365.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Many classification schemes have been proposed for ductal carcinoma in situ. Architectural heterogeneity is widely recognized. Cytonuclear grade appears to have greater prognostic significance than architectural pattern. This study assesses heterogeneity using a classification based on cytological grade and compares this to architectural heterogeneity in mammographically detected ductal carcinoma in situ. One hundred and twelve cases were classified according to architectural subtypes and the carcinoma nuclei were graded. Necrosis and microcalcification were assessed. Eighty-four percent of ductal carcinomas in situ had a single nuclear grade, whereas only 39% showed a single architectural pattern. High grade nuclei were present in 87% of cases. Necrosis was associated with high nuclear grade. In contrast to architectural heterogeneity, this study shows little ductal carcinoma in situ heterogeneity when classification is based on nuclear grade. Thus, a cytomorphological classification should have the advantage of consistency and reproducibility in comparison to architecture-based classification systems.
引用
收藏
页码:445 / 450
页数:6
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