Selective expression of an interleukin-12 receptor component by human T helper 1 cells

被引：654

作者：

Rogge, L ^{[1
]}

BarberisMaino, L ^{[1
]}

Biffi, M ^{[1
]}

Passini, N ^{[1
]}

Presky, DH ^{[1
]}

Gubler, U ^{[1
]}

Sinigaglia, F ^{[1
]}

机构：

[1] HOFFMANN LA ROCHE INC,DEPT INFLAMMAT AUTOIMMUNE DIS,NUTLEY,NJ 07110

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1997年 / 185卷 / 05期

关键词：

D O I：

10.1084/jem.185.5.825

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-12 (IL-12), a heterodimeric cytokine produced by activated monocytes and dendritic cells, plays a crucial role in regulating interferon (IFN)-gamma production and in the generation of IFN-gamma-producing T helper 1 (Th1) cells. Here we show that the IL-12 receptor (IL-12R) beta 2 subunit, a recently cloned binding and signal transducing component of the IL-12R, is expressed on human Th1 but not Th2 clones and is induced during differentiation of human naive cells along the Th1 but not the Th2 pathway. IL-12 and type I but not type II interferons induce expression of the IL-12R beta 2 chain during in vitro T cell differentiation after antigen receptor triggering. The selective expression and regulation of the IL-12R beta 2 subunit may help to understand the basis of Th1/Th2 differentiation and may provide therapeutic options for altering the Th1/Th2 balance in several immune-pathological conditions such as autoimmune diseases and allergies.

引用

页码：825 / 831

页数：7

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