MicroRNA-23b downregulates peroxiredoxin III in human prostate cancer

被引：65

作者：

He, Hui-chan ^{[1
]}

Zhu, Jian-guo ^{[2
,4
]}

Chen, Xi-bin ^{[1
]}

Chen, Shan-ming ^{[1
]}

Han, Zhao-dong ^{[1
]}

Dai, Qi-shan ^{[1
]}

Ling, Xiao-hui ^{[1
]}

Fu, Xin ^{[1
]}

Lin, Zhuo-yuan ^{[1
]}

Deng, Ye-han ^{[1
]}

Qin, Guo-qiang ^{[1
]}

Cai, Chao ^{[1
]}

Chen, Jia-hong ^{[1
]}

Zhong, Wei-de ^{[1
,2
,3
]}

机构：

[1] Guangzhou Med Univ, Dept Urol, Guangzhou Municipal Peoples Hosp 1, Guangdong Key Lab Clin Mol Med & Diagnost, Guangzhou 510180, Guangdong, Peoples R China

[2] So Med Univ, Guangdong Prov Inst Nephrol, Guangzhou 510515, Guangdong, Peoples R China

[3] Guangzhou Med Univ, Urol Key Lab Guangdong Prov, Guangzhou 510230, Guangdong, Peoples R China

[4] Guizhou Prov Peoples Hosp, Dept Urol, Guizhou 550002, Peoples R China

来源：

FEBS LETTERS | 2012年 / 586卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Prostate cancer; MicroRNA-23b; Peroxiredoxin III; Clinicopathological feature; Biochemical recurrence-free survival; OXIDATIVE STRESS; TARGET; EXPRESSION; OVEREXPRESSION; IDENTIFICATION; REVEALS; CELLS;

D O I：

10.1016/j.febslet.2012.06.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

To investigate the mechanism by which peroxiredoxin III (PRDX3) is altered in human prostate cancer (PCa), we used microRNA (miRNA) target prediction program and miRNA microarray to predict and identify miR-23b as a candidate miRNA that targets PRDX3. We showed that miR-23b suppresses PRDX3 protein expression in human DU145 cells under normal and hypoxic conditions. Additionally, the clinical significance of miR-23b and PRDX3 expression in PCa patients was also confirmed. In conclusion, our data suggest that the effects of PRDX3 in PCa progression may be caused by the regulation function of miR-23b, and consequently, miR-23b may be involved in the response of PCa cells to hypoxia stress. Crown Copyright (c) 2012 Published by Elsevier B.V. on behalf of Federation of European Biochemical society. All rights reserved.

引用

页码：2451 / 2458

页数：8

共 32 条

[1]

Differential Expression of Peroxiredoxins in Prostate Cancer: Consistent Upregulation of PRDX3 and PRDX4 [J].