Forty-Year Journey of Angiogenesis Translational Research

被引：181

作者：

Cao, Yihai ^{[1
,2
]}

Arbiser, Jack ^{[3
]}

D'Amato, Robert J. ^{[4
,5
]}

D'Amore, Patricia A. ^{[6
]}

Ingber, Donald E. ^{[4
,7
,8
]}

Kerbel, Robert ^{[9
]}

Klagsbrun, Michael ^{[4
,5
]}

Lim, Sharon ^{[1
]}

Moses, Marsha A. ^{[4
,5
]}

Zetter, Bruce ^{[4
,5
]}

Dvorak, Harold ^{[10
]}

Langer, Robert ^{[11
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden

[2] Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden

[3] Emory Univ, Sch Med, Atlanta Vet Adm Hlth Ctr, Dept Dermatol, Atlanta, GA 30322 USA

[4] Childrens Hosp, Vasc Biol Program, Boston, MA 02115 USA

[5] Childrens Hosp, Dept Surg, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Dept Ophthalmol, Schepens Eye Res Inst, Boston, MA 02114 USA

[7] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[9] Sunnybrook Hlth Sci Ctr, Div Mol & Cellular Biol Res, Toronto, ON M4N 3M5, Canada

[10] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Vasc Biol Res Ctr, Boston, MA 02215 USA

[11] MIT, Koch Inst Integrat Canc Res, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2011年 / 3卷 / 114期

基金：

欧洲研究理事会; 瑞典研究理事会;

关键词：

VASCULAR ENDOTHELIAL GROWTH; RECOMBINANT HUMAN ENDOSTATIN; BEVACIZUMAB PLUS IRINOTECAN; TUMOR-BEARING MICE; MALIGNANT GLIOMA; ANTI-VEGF; IN-VIVO; ANTIANGIOGENIC THERAPY; PERMEABILITY FACTOR; CELLS SECRETE;

D O I：

10.1126/scitranslmed.3003149

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Forty years ago, Judah Folkman predicted that tumor growth is dependent on angiogenesis and that inhibiting this process might be a new strategy for cancer therapy. This hypothesis formed the foundation of a new field of research that represents an excellent example of how a groundbreaking scientific discovery can be translated to yield benefits for patients. Today, antiangiogenic drugs are used to treat human cancers and retinal vascular diseases. Here, we guide readers through 40 years of angiogenesis research and discuss challenges of antiangiogenic therapy.

引用

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