Induction of brain-derived neurotrophic factor (BDNF) and the receptor trk B mRNA following middle cerebral artery occlusion in rat

被引：67

作者：

Arai, S ^{[1
]}

Kinouchi, H ^{[1
]}

Akabane, A ^{[1
]}

Owada, Y ^{[1
]}

Kamii, H ^{[1
]}

Kawase, M ^{[1
]}

Yoshimoto, T ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,DEPT NEUROSURG,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

来源：

NEUROSCIENCE LETTERS | 1996年 / 211卷 / 01期

关键词：

focal cerebral ischemia; spreading depression; brain-derived neurotrophic factor; tyrosine kinase receptor; hippocampus;

D O I：

10.1016/0304-3940(96)12720-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced brain-derived neurotrophic factor (BDNF) and the receptor, Irk B mRNA, in brain. In situ hybridization studies showed that BDNF and Irk B mRNAs were induced in a widespread region of the ipsilateral cortex outside the infarct at 4 h following MCA occlusion. They were also induced in the bilateral hippocampi which are remote from the ischemic MCA region. These data show that changes in neurotrophic factor and receptor gene expressions can occur in the areas outside the infarct which could survive.

引用

页码：57 / 60

页数：4

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