Small RNA-directed heterochromatin formation in the context of development: What flies might learn from fission yeast

被引：24

作者：

Huisinga, Kathryn L. ^{[1
]}

Elgin, Sarah C. R. ^{[1
]}

机构：

[1] Washington Univ, Dept Biol, St Louis, MO 63130 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2009年 / 1789卷 / 01期

关键词：

Heterochromatin; Drosophila melanogaster; Small RNA; S; pombe; Transposable element; Cell cycle; DROSOPHILA-MELANOGASTER DEVELOPMENT; EMBRYONIC AXIS SPECIFICATION; POSITION-EFFECT VARIEGATION; SELFISH GENETIC ELEMENTS; POLE CELL-FORMATION; TELOMERE ELONGATION; ENDOGENOUS SIRNAS; DNA METHYLATION; SOMATIC-CELLS; GERM-LINE;

D O I：

10.1016/j.bbagrm.2008.08.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A link between the RNAi system and heterochromatin formation has been established in several model organisms including Schizosaccharomyces pombe and Arabidopsis thaliana. However, the data to support a role for small RNAs and the associated machinery in transcriptional gene silencing in animal systems is more tenuous. Using the S. pombe system as a model, we analyze the role of small RNA pathway components and associated small RNAs in regulating transposable elements and potentially directing heterochromatin formation at these elements in Drosophila melanogaster. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：3 / 16

页数：14

共 144 条

[21] cutoff and aubergine mutations result in retrotransposon upregulation and checkpoint activation in Drosophila
Chen, Yu
Pane, Attilio
Schupbach, Trudi
[J]. CURRENT BIOLOGY, 2007, 17 (07) : 637 - 642
[22] Endogenous RNA interference provides a somatic Defense against Drosophila transposons
Chung, Wei-Jen
Okamura, Katsutomo
Martin, Raquel
Lai, Eric C.
[J]. CURRENT BIOLOGY, 2008, 18 (11) : 795 - 802
[23] Histone methylation is required for oogenesis in Drosophila
Clough, Emily
Moon, Woongjoon
Wang, Shengxian
Smith, Kathleen
Hazelrigg, Tulle
[J]. DEVELOPMENT, 2007, 134 (01): : 157 - 165
[24] Coupling of double-stranded RNA synthesis and siRNA generation in fission yeast RNAi
Colmenares, Serafin U.
Buker, Shane M.
Buhler, Marc
Dlakic, Mensur
Moazed, Danesh
[J]. MOLECULAR CELL, 2007, 27 (03) : 449 - 461
[25] The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification
Cook, HA
Koppetsch, BS
Wu, J
Theurkauf, WE
[J]. CELL, 2004, 116 (06) : 817 - 829
[26] A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal
Cox, DN
Chao, A
Baker, J
Chang, L
Qiao, D
Lin, HF
[J]. GENES & DEVELOPMENT, 1998, 12 (23) : 3715 - 3727
[27] CSINK AK, 1994, GENETICS, V138, P153
[28] An endogenous small interfering RNA pathway in Drosophila
Czech, Benjamin
Malone, Colin D.
Zhou, Rui
Stark, Alexander
Schlingeheyde, Catherine
Dus, Monica
Perrimon, Norbert
Kellis, Manolis
Wohlschlegel, James A.
Sachidanandam, Ravi
Hannon, Gregory J.
Brennecke, Julius
[J]. NATURE, 2008, 453 (7196) : 798 - U7
[29] Chp1-Tas3 interaction is required to recruit RITS to fission yeast centromeres and for maintenance of centromeric heterochromatin
DeBeauchamp, Jennifer L.
Moses, Arian
Noffsinger, Victoria J. P.
Urich, Dagny L.
Job, Godwin
Kosinski, Aaron M.
Partridge, Janet F.
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (07) : 2154 - 2166
[30] miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis
Deng, W
Lin, HF
[J]. DEVELOPMENTAL CELL, 2002, 2 (06) : 819 - 830

← 1 2 3 4 5 6 7 8 9 10 →