Shell cross-linked polymer micelles: stabilized assemblies with great versatility and potential

被引：68

作者：

Thurmond, KB ^{[1
]}

Huang, HY ^{[1
]}

Clark, CG ^{[1
]}

Kowalewski, T ^{[1
]}

Wooley, KL ^{[1
]}

机构：

[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 1999年 / 16卷 / 1-4期

基金：

美国国家科学基金会;

关键词：

shell; cross-linked; block; copolymer; nanospheres;

D O I：

10.1016/S0927-7765(99)00060-0

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Shell cross-linked polymer micelles have been introduced within the past 3 years, and they have already demonstrated great promise as robust nanostructured core-shell nanospheres. The formation of cross-links throughout the shell of polymer micelles offers stability to the nanostructured assemblies, by providing reinforcement to the weak interactions that facilitate polymer micelle existence. Cross-linking can be accomplished by direct reaction between the chain segments located within the polymer micelle shell, or via addition of multi-functional cross-linking reagents. The dimensions; composition, and properties of each of the domains of the polymer micelles can be controlled by selection of diblock copolymer composition, conditions for polymer micelle assembly, and chemistry used for cross-linking. An overview of each of the examples of SCK nanospheres currently known is presented here. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：45 / 54

页数：10

共 39 条

[1]

ALEXANDRIDIS P, 1996, POLYM MAT ENCY, V1, P743

[2]

Arca E, 1995, INT J POLYM ANAL CH, V2, P31

[3] Location of fluorotryptophan sequestered in an amphiphilic nanoparticle by rotational-echo double-resonance NMR [J].