2-Chlorodeoxyadenosine (2-CdA) in 2-hour versus 24-hour intravenous infusion in the treatment of patients with hairy cell leukemia

被引：36

作者：

Robak, T

BlasinskaMorawiec, M

Krykowski, E

Hansz, J

Komarnicki, M

Kazimierczak, M

Konopka, L

Maj, S

Hellmann, A

Zaucha, JM

Urasinski, L

Zdziarska, B

KotlarekHaus, S

UsnarskaZubkiewicz, L

Kuratowska, Z

DwilewiczTrojaczek, J

Holowiecki, J

KrawczykKulis, M

Grieb, P

机构：

[1] 2nd Department of Internal Medicine, Med. Univ. of Lódź, Poznañ

[2] Department of Hematology, Academy of Medicine, Poznañ

[3] Inst. of Hematol. and Transfusiology, Warsaw

[4] Department of Hematology, Univ. Med. School of Gdańsk, Szczecin

[5] Department of Hematology, Institute of Internal Medicine, Pomorian Academy of Medicine, Szczecin

[6] Department of Hematology, Academy of Medicine, Wroclaw

[7] Department of Hematology, Academy of Medicine, Warsaw

[8] Department of Hematology, Silesian Academy of Medicine, Katowice

[9] Medical Research Center, Polish Academy of Sciences, Warsaw

[10] Department of Internal Medicine, Med. Univ. of Lódź, 93-513 Lódz

来源：

LEUKEMIA & LYMPHOMA | 1996年 / 22卷 / 1-2期

关键词：

2-chlorodeoxyadenosine; hairy cell leukemia; efficiency; side effects;

D O I：

10.3109/10428199609051736

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Forty one patients with hairy cell leukemia (HCL) were treated with 2-chloro-deoxyadenosine (2-CdA) administered in various schedules. Complete remission (CR) was achieved in 31 (76%) patients and partial remission (PR) in 9 (22%). The mean duration of remission (CR + PR) was 25.2 months (range 9-45 months). One patient did not respond to therapy. Twelve out of 16 patients (75%) achieved CR after 5-day intravenous infusions of 2-CdA and 19 out of 25 patients (76%) after 7-day courses. In 19 out of 23 patients (82.6%) CR was achieved after intermittent 2-hour infusions and in 12 out of 18 (66.7%) after continuous 24-hour infusion. The differences were not statistically significant. Side effects of 2-CdA were similar in both groups except for infections, which were less frequently observed in the group treated for 5 days. The results of our study suggest that 2-CdA can be effectively administered to patients with HCL using 5-day courses and a 2-hour daily infusion.

引用

页码：107 / 111

页数：5

共 23 条

[21] SPLENECTOMY VS ALPHA-INTERFERON - A RANDOMIZED STUDY IN PATIENTS WITH PREVIOUSLY UNTREATED HAIRY-CELL LEUKEMIA [J].