Enantioselective conjugate radical addition reactions mediated by chiral Lewis acid complexes of (R,R)-4,6-dibenzofurandiyl-2,2′-bis(4-phenyloxazoline) (DBFOX/Ph)

被引：61

作者：

Iserloh, U

Curran, DP ^{[1
]}

Kanemasa, S

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

[2] Kyushu Univ, Inst Adv Mat Study, Kasuga, Fukuoka 8168580, Japan

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 12期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0957-4166(99)00238-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A high-yielding synthesis (50% overall yield) of tridentate bisoxazoline ligand (R,R)-4,6-dibenzofurandiyl-2,2'-bis(4-phenyloxazoline) (DBFOX/Ph) was developed. DBFOX/Ph was subsequently tested in enantioselective conjugate radical additions onto 3-(3-phenyl-2-propenoyl)-2-oxazolidinone Two dozen Lewis acids were evaluated, and Mg(ClO4)(2) emerged as the best Lewis acid in terms of yield and enantioselectivity (100% yield, 75.4% ee (S)). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2417 / 2428

页数：12

共 29 条

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