Isolation, characterization and chromosomal assignment of the human WNT7A gene

被引：27

作者：

Ikegawa, S

Kumano, Y

Okui, K

Fujiwara, T

Takahashi, E

Nakamura, Y

机构：

[1] OTSUKA PHARMACEUT CO LTD,DIV DIAGNOST,OTSUKA ASSAY LABS,TOKUSHIMA 77101,JAPAN

[2] OTSUKA PHARMACEUT CO LTD,OTSUKA GEN RES INST,TOKUSHIMA 77101,JAPAN

来源：

CYTOGENETICS AND CELL GENETICS | 1996年 / 74卷 / 1-2期

关键词：

D O I：

10.1159/000134404

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Wnt genes compose a large gene family encoding a group of secreted signaling molecules that have been implicated in oncogenesis and a number of developmental processes. We have isolated a full-length human cDNA clone that we consider to be a novel member of the Wnt gene family. The gene (WNT7A) encodes a deduced 349-amino-acid peptide with 98% identity in amino acid sequence to murine Wnt7a. Expression of this gene is restricted to certain tissues: placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Furthermore, we have isolated a genomic clone of WNT7A and mapped it to chromosome 3p25 by fluorescent in situ hybridization.

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页码：149 / 152

页数：4

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