ISOLATION AND GENETIC-MAPPING OF 2 NOVEL MEMBERS OF THE MURINE WNT GENE FAMILY, WNT11 AND WNT12, AND THE MAPPING OF WNT5A AND WNT7A

被引：36

作者：

ADAMSON, MC

DENNIS, C

DELANEY, S

CHRISTIANSEN, J

MONKLEY, S

KOZAK, CA

WAINWRIGHT, B

机构：

[1] UNIV QUEENSLAND,CTR MOLEC BIOL & BIOTECHNOL,ST LUCIA,QLD 4072,AUSTRALIA

[2] NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892

来源：

GENOMICS | 1994年 / 24卷 / 01期

关键词：

D O I：

10.1006/geno.1994.1575

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The murine Wnt genes are implicated in the control of a variety of developmental processes. Using a PCR-based approach, we have isolated two novel members of the murine Wnt gene family, Wnt11 and Wnt12. These cDNAs display an amino acid sequence identity of between 38 and 49% with all other murine Wnts over the regions that we have isolated. In addition, two previously described Wnt genes, Wnt5a and Wnt7a, were detected in RT-PCR products. Interspecific crosses were used to demonstrate close linkage between Wnt12 and Wnt1 on Chromosome (Chr) 15. Wnt7a was mapped to mouse Chr 6, Wnt5a to the centromeric region of Chr 14, and Wnt11 to Chr7. (C) 1994 Academic Press,Inc.

引用

页码：9 / 13

页数：5

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